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Dana-Farber research leads to better understanding of the immune system in kidney cancer

Dana-Farber research leads to better understanding of the immune system in kidney cancer
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United States , Dana Farber Cancer Institute , City Of , United Kingdom , Lauren Hirsch , Sara Napolitano , Nicholas Schindler , Davida Braun , Michael Brigham , Dana Farber Brigham , Gabrielle Bouchard , Orit Rozenblatt Rosen , Laura Dellostritto , Angie Mayorga , Van Allen , John Steinharter , Catherinej Wu , Ziad Bakouny , Kellyp Burke , Wenxin Xu , Satyenh Gohil , Lucas Pomerance , Rizwan Haq , Bristol Myers Squibb , Jingyi Wu , Tonik Choueiri ,

Researchers uncover potentially promising therapeutic combination for renal cell carcinoma

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Boston, Mass. Renal cell carcinoma (RCC) is the most common form of cancer of the kidney. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide. Currently, the 5-year survival rate for patients with metastatic RCC is only about 12 percent. Current treatments include inhibitors of the VEGF and PD-1 pathways. However, resistance to therapy occurs in most patients and new combination treatments are still needed to enhance the efficacy of these current approaches.
Now, investigators have demonstrated that ACE2 expression is a good prognostic factor in RCC, that loss of ACE2 mediates resistance to classical treatments, and that in preclinical models, treatment with a drug that is downstream of ACE2 can improve tumor responses in RCC and significantly prolong survival. The team, led by Beth Israel Deaconess Medical Center s (BIDMC) Rupal Bhatt, MD, PhD, and University College Cork, Ireland s Thomas Walther, PhD, ....

United States , Dana Farber Cancer Institute , Andrew Moore , Chun Hau Chen , Carol Ocallaghan , Sabina Signoretti , Maura Naughton , Rupal Bhatt , Seema Amin , Ziad Bakouny , Ruchi Saxena , Patrick Neset Joslin , Prateek Khanna , Paul Catalano , Thomas Walther , Manoj Bhasin , Tonik Choueiri , Rana Mckay , Constant Pharmaceuticals , National Institutes Of Health Funding , University College Cork , Beth Israel Deaconess Medical Center , Harvard Medical School , Science Foundation Ireland , Science Translational , Harvard Medical ,