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Diet + exercise + chemo = increased survival in youth with leukemia


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Los Angeles (April 1, 2021) Overweight children and adolescents receiving chemotherapy for treatment of leukemia are less successful battling the disease compared to their lean peers. Now, research conducted at the Cancer and Blood Disease Institute at Children s Hospital Los Angeles indicates that modest changes in diet and exercise can greatly increase survival in youth treated for acute lymphoblastic leukemia (ALL), the most common childhood cancer.
To our knowledge, this is the first study to show that by limiting calories and increasing exercise we can make chemotherapy more effective in eliminating leukemia cells within the first month of therapy, decreasing the chances of disease relapse in children and adolescents, says Principal Investigator Etan Orgel, MD, MS, Director of the Medical Supportive Care Service in the Cancer and Blood Disease Institute at Children s Hospital Los Angeles. The study is published in the American Society of Hematology s jou ....

United States , Los Angeles , Steven Mittelman , Matthew Oberley , Weili Sun , Deepa Bhojwani , Jonathan Tucci , David Freyer , Alan Wayne , Christina Dieli Conwright , Etan Orgel , Rubi Buxton , Celia Framson , Ji Yoon Kim , Keck School Of Medicine , Jonsson Comprehensive Cancer Center , American Society Of Hematology , Gabrielle Angel Foundation For Cancer Research , Janssen Pharmaceuticals , Dana Farber Cancer Institute , Caris Life Sciences , Supportive Care Service , Blood Disease Institute , Hospital Los Angeles , Principal Investigator Etan Orgel , Medical Supportive Care Service ,

Low-calorie diet and mild exercise improve survival for young people with leukemia


UCLA
“We hoped the intervention would improve outcomes, but we had no idea it would be so effective,” said Dr. Steven Mittelman, chief of pediatric endocrinology at UCLA Mattel Children’s Hospital.
Low-calorie diet and mild exercise improve survival for young people with leukemia
Those participating in the intervention were 70% less likely to have detectable cancer cells after one month of treatment
Low-calorie diet and mild exercise improve survival for young people with leukemia
Those participating in the intervention were 70% less likely to have detectable cancer cells after one month of treatment
UCLA
“We hoped the intervention would improve outcomes, but we had no idea it would be so effective,” said Dr. Steven Mittelman, chief of pediatric endocrinology at UCLA Mattel Children’s Hospital. ....

United States , Dana Farber Cancer Institute , Steven Mittelman , Matthew Oberley , Weili Sun , Los Angeles , David Freyer , Jonathan Tucci , Christina Dieli Conwright , Etan Orgel , Rubi Buxton , Celia Framson , Ji Yoon Kim , Vanderbilt University Medical Center , National Cancer Institute , Blood Disease Institute , National Institutes Of Health , Jonsson Comprehensive Cancer Center , American Society Of Hematology , Gabrielle Angel Foundation For Cancer Research , Hospital Los Angeles , Comprehensive Cancer , American Society , Blood Advances , Hospital Los , Gabrielle Angel Foundation ,