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Study highlights metabolite targets for depression prevention that are easily modifiable through diet interventions

Researchers used a UHPLC and mass spectrometry-based Metabolon platform to identify and characterize circulating metabolites associated with depression. ....

Zuid Holland , Artemisdiana Shutterstock , Sophia Coveney , Neha Mathur , Neha Mathuraug , Study Of Health , Health Research , Molecular Psychiatry , Rotterdam Study , Cooperative Health Research , Netherlands Epidemiology , European Prospective Investigation , Mendelian Randomization , Rare Disease , United Kingdom Biobank , Gut Brain Axis , Liquid Chromatography , Mass Spectrometry , Vitamin A , Vitamin K ,

Coronary Artery Calcium Scores May improve CHD Risk Discrimination

An analysis of 2 population-based cohorts suggests coronary artery calcium scores added to traditional risk-based models showed better discrimination than polygenic risk scores for CHD risk prediction. ....

United States , Zuid Holland , Sadiyas Khan , Northwestern University Sadiyas Khan , Northwestern University Feinberg School Of Medicine , Northwestern University , Northwestern University Feinberg School , Multi Ethnic Study , Rotterdam Study ,

Coronary artery calcium score, not polygenic risk score, best predicts heart disease risk

Data show CV risk discrimination improved when adding a coronary artery calcium score to a CHD prediction model based on traditional risk factors; however, there were no changes when adding a polygenic risk score.The analysis of two large cohorts of middle-age and older adults with long-term follow-up — all with available genetic data and coronary CT scans — addresses a key knowledge ....

United States , Sadiya Sana Khan , American Heart Association , Northwestern University Feinberg School Of Medicine , Northwestern University Feinberg School , Multi Ethnic Study , Rotterdam Study , Sana Khan ,

Coronary Artery Calcium Score Beats Polygenic Risk Score at Heart Disease Risk Prediction

The combination of the two scores also had no additive predictive power compared with the coronary artery calcium score alone, the researchers found. ....

Zuid Holland , Sadiya Khan , Northwestern University Feinberg School Of Medicine , Scientific Statement , Northwestern University Feinberg School , Multi Ethnic Study , Rotterdam Study ,

Heart disease: CT scans may be best for predicting mid-life risk

A new study suggests that CT scans used in conjunction with traditional risk markers can help doctors assess individual coronary heart disease risk more accurately than genetic testing in middle aged and older adults. ....

Zuid Holland , United States , Erica Spatz , Raimund Erbel , Karole Watson , Josephf Polak , Sadiyas Khan , Urs Siedentop Co Stocksy , University Of Duisburg , Tufts University School Of Medicine , World Health Organization , Yale University , Northwestern University , David Geffen School Of Medicine , Northwestern University Feinberg School Of Medicine , University Of California Los Angeles , Essen University Hospital , Health Organization , Heinz Nixdorf Recall , Northwestern University Feinberg School , Ethnic Study , Rotterdam Study , Cohort Equations , Tufts University School , Medical News Today , Heinz Nixdorf Recall Study ,