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Single Injection May Revolutionize Melanoma Treatment

Single Injection May Revolutionize Melanoma Treatment
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Shari Pilon Thomas , Amoda Sarnaik , Moffitt Cancer Center , Moffitt Immunology Program , Moffitt Cutaneous Oncology Program , Rose Bengal , Cutaneous Oncology ,

First record of the human infection of Brucella melitensis in Kyrgyzstan: evidence from whole-genome sequencing-based analysis | Infectious Diseases of Poverty

Brucellosis, a zoonosis mainly transmitted by consumption of unpasteurized dairy products as well as direct contact with infected animals, is endemic in Kyrgyzstan. However, Brucella species in humans have not been investigated and the origin of the disease remains poorly known in wide parts of Сentral Asia. Thus, molecular characterization of the circulating strains is a critical first step in understanding Brucella diversity in the country. In this study, isolates were collected from patients with suspected brucellosis from different regions in Kyrgyzstan between 2019 and 2020. The detection and identification of Brucella was carried out by Bruce-ladder PCR. Next generation sequencing was used to sequence the 89 Brucella isolates, which were genotyped by cgSNP and cgMLST to identify epidemiological connection between Brucella isolates as well as placing them in the context of the global Brucella phylogeny. The Brucella strains isolated from all regions of Kyrgyzstan were identi ....

United States , Republican Center , Dangerous Infections Ministry Of Health , Mediterranean Basin , Middle East , South America , Rose Bengal , Soviet Republic , Highly Dangerous Infections Ministry ,