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Innate Protection Against Ebola Discovered

Innate Protection Against Ebola Discovered
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Penn scientists discover a cellular pathway that keeps Ebola virus from exiting human cells

In their evolutionary battle for survival, viruses have developed strategies to spark and perpetuate infection. Once inside a host cell, the Ebola virus, for example, hijacks molecular pathways to replicate itself and eventually make its way back out of the cell into the bloodstream, where it can spread further. ....

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Blocking viruses' exit strategy


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IMAGE: Marburg virus-like-particles (in green, which are not infectious) bud, or exit from the surface of a host cell. A host protein (in yellow) helps the VLPs bud. Research by Penn.
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Credit: Penn Vet Microscopy Core Facility
The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.
A team of researchers is working to change that. In a new paper in the journal
Antimicrobial Agents and Chemotherapy, investigators from Penn s School of Veterinary Medicine, working together with scientists from the Fox Chase Chemical Diversity Center and the Texas Biomedical Research Institute, report encouraging results from tests of an experimental antiviral targeting Marburg virus. The compound blocks the virus from departing infected ....

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