A growing repertoire of cell and molecule-based immunotherapies is offering patients with indomitable cancers new hope by mobilizing their immune systems against tumor cells.
Adding immunity to human kidney-on-a-chip advances cancer drug testing sciencedaily.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencedaily.com Daily Mail and Mail on Sunday newspapers.
T cell bispecific antibodies (TCBs) are an emerging class of immunotherapeutics with several TCBs approved by the FDA for the treatment of leukemias, lymphomas, and myelomas. TCBs label tumor cells with one of their ends, and attract immune cells with another end to coerce them into tumor cell killing. However, one major challenge in the development of TCBs are “on-target, off-tumor” toxicities at sites in the body that also express TCB-targeted antigens. A new collaboration of Jennifer Lewis’ group and researchers from the Roche Innovation Centers in Switzerland and Germany now created an immune-infiltrated human kidney organoid-on-chip model that allows kidney toxicity of TCBs.
Adding immunity to human kidney-on-a-chip adv eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.