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Mutations in histone regulator protein linked to rare neurodevelopmental disorder, cancers

Mutations in a histone regulator protein are linked to both a rare neurodevelopmental disorder and to some cancers, according to a study published in the journal Genes and Development. ....

Robert Francis Furchgott , Michael Keogh , Marc Morgan , Ali Shilatifard , Emily Henderson , Simpson Querrey Institute For Epigenetics , National Institutes Of Health , Roberth Lurie Comprehensive Cancer Center , Northwestern University , Molecular Genetics , Robert Francis Furchgott Professor , Simpson Querrey Institute , Comprehensive Cancer Center , National Institutes , Cell Proliferation , Ene Expression ,

Three Feinberg Faculty Elected to National Academy of Medicine

Elizabeth McNally, MD, PhD; Melissa Simon, MD, MPH; and Guillermo Ameer, ScD; have been elected to the National Academy of Medicine. ....

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Scientists identify a critical checkpoint in transcription elongation

Scientists identify a critical checkpoint in transcription elongation
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David Julius and Ardem Patapoutian win the Frontiers of Knowledge Award in Biomedicine

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Credit: BBVA Foundation
The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), for identifying the receptors that enable us to sense temperature, pain and pressure.
Temperature, pain and pressure are part of our sense of touch, perhaps the least understood of the five main senses of humans, read the opening words of the citation. Julius and Patapoutian provided a molecular and neural basis for thermosensation and mechanosensation.
This line of research holds out exciting medical possibilities, because it sheds light on how to reduce chronic and acute pain associated with a range of diseases, trauma and their treatments. In fact, several pharmaceutical laboratories are working to identify molecules that act on these receptors with the aim of treati ....

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