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Researchers at Duke Human Vaccine Institute (DHVI) have identified a new type of anti-glycan antibody (Ab) that binds to a patch of the chain-like sugars on the outer shell of HIV, effectively neutralizing the virus. The newly identified antibodies, which the team found in both macaques and humans, could lead to development of a novel vaccine strategy that might potentially be used against SARS-CoV-2 and fungal pathogens.
“This represents a new form of host defense,” said Barton Haynes, MD, director of the Duke Human Vaccine Institute (DHVI). “These new antibodies have a special shape and could be effective against a variety of pathogens. It’s very exciting.”