Researchers at the Center for Research on Redox Processes in Biomedicine (Redoxome) in Brazil have identified extracellular matrix proteins modified by the action of hypobromous acid in normal and fibrotic lung tissues, suggesting a possible physiological role for protein bromination. This is the first study to identify brominated proteins in pulmonary fibrosis and non-fibrotic lung tissue.
Research Sheds Light on Cellular Energy Metabolism Regulation
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Study elucidates how energy metabolism is regulated at cellular level
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IMAGE: Image of a mitofusin-2 deficient egg shows mitochondria [stained green] to be fewer, more aggregated, and swollen than in controls view more
Credit: Marcos Chiaratti
A Brazilian study published in the journal
Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research.
According to the authors, transgenerational transmission of metabolic diseases may be associated with Mfn2 deficiency in the mother s oocytes (immature eggs). Mfn2 refers to mitofusin-2, a protein involved in the regulation of vascular smooth muscle cell proliferation. It is normally found in the outer membrane of mitochondria, the organelles that supply cells with energy. A deficiency leads to mitochondrial swelling and dysfunction, as well as altering the expression of almost 1,000 genes in female gametes.