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Compound may prevent risk of form of arrhythmia from common medications | The Source

Multi-institutional team combined expertise to make discovery
May 17, 2021
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Dozens of commonly used drugs, including antibiotics, anti-nausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart’s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Institute For Data Science , Skandalaris Center , Institute Of Clinical , Entrepreneurial Acceleration Program , Office Of Technology Management , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office , Technology Management ,

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these medications when taken in combination. The team found that the compound, named C28, not only prevents or reverses the negative physiological effects on the action potential, ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Emily Henderson , Institute For Data Science , Skandalaris Center , Office Of Technology Management , Institute Of Clinical , Entrepreneurial Acceleration Program , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office ,

Compound may prevent risk of a form of arrhythmia from common medications

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IMAGE: Xiaoqin Zou, professor of physics, biochemistry, and a member of the Dalton Cardiovascular Research Center and Institute for Data Science and Informatics at the University of Missouri
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Credit: University of Missouri
Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs may have a more therapeutic benefit at higher doses, but are limited by the risk of arrhythmia.
Through both computational and experimental validation, a multi-institutional team of researchers has identified a compound that prevents the lengthening of the heart s electrical event, or action potential, resulting in a major step toward safer use and expanded therapeutic efficacy of these med ....

Jianmin Cui , Mira Cohen , Xiaoqin Zou , Institute For Data Science , Skandalaris Center , Institute Of Clinical , Entrepreneurial Acceleration Program , Office Of Technology Management , Washington University Office Of Technology Management , Translational Sciences , University Of Missouri , Research Innovation In Biotechnology , Proceedings Of The National Academy Sciences , Dalton Cardiovascular Research Center , Washington University In St , Institute For Molecular Cardiology , National Academy , Mckelvey School , Washington University , Distinguished Professor , Molecular Cardiology , Renaissance School , Stony Brook University , Data Science , Washington University Office , Technology Management ,

Analysis Group Welcomes New Affiliates and Announces Senior-Level Promotions

Analysis Group Welcomes New Affiliates and Announces Senior-Level Promotions
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