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KCSM CCTV News December 1, 2013

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MHRA Clinical Trials Scheme

MHRA Clinical Trials Scheme
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Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial

Objective To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.

Design Randomised controlled trial.

Setting Participants’ homes and communities at five sites in the United Kingdom.

Participants 365 adults with early dementia or mild cognitive impairment who were living at home, and family members or carers.

Intervention The intervention, Promoting activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED), was a specially designed, dementia specific, rehabilitation programme focusing on strength, balance, physical activity, and performance of activities of daily living, which was tailored and progressive and addressed risk and the psychological needs of people with dementia. Up to 50 therapy sessions were provided over 12 months. The control group received usual care plus a falls risk assessment. Pro ....

United Kingdom , Noord Holland , Care Research , Care Research Join Dementia , Research Application System , National Health Service , Department Of Health , Research Council , Bangor University , English National Dementia Strategy , Bradford Leeds Research Ethics Committee , National Institute For Health , Early Dementia , Promoting Activity , National Institute , Statistical Manual , Longitudinal Ageing Study , Amsterdam Physical Activity Questionnaire , Misfit Shine , Hand Dynamometer , Longitudinal Aging Study , United Kingdom Government , North Wales Organisation , Randomised Trials , Health Clinical Trials Unit , Medical Research Council ,

Short stature and language development in the United Kingdom: a longitudinal analysis of children from the Millennium Cohort Study | BMC Medicine

In low- and middle-income countries, poverty and impaired growth prevent children from meeting their cognitive developmental potential. There are few studies investigating these relationships in high-income settings. Participants were 12,536 children born between 2000 and 2002 in the UK and participating in the Millennium Cohort Study (MCS). Short stature was defined as having a height-for-age 2 or more standard deviations below the median (≤ − 2 SDS) at age 3 years. Standardized British Abilities Scales II (BAS II) language measures, used to assess language development at ages 3, 5, 7 and 11 years, were the main outcome assessed. Children with short stature at age 3 years (4.1%) had language development scores that were consistently lower from ages 3 to 11 years (− 0.26 standard deviations (SD) (95% CI − 0.37, − 0.15)). This effect was attenuated but remained significant after a ....

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