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Dr Ari Green on Promising Remyelination Therapies and Patient Outcomes in MS

Ari Green, MD, University of California, San Francisco, discusses the promising results observed in current remyelination trials in multiple sclerosis (MS) and the patient-specific features that may influence therapy outcomes. ....

San Francisco , United States , United Kingdom , Americas Committee For Treatment , University Of California , Bari Green , Americas Committee , Neural Repair , Multiple Sclerosis ,

Myelin damaged by multiple sclerosis could be repaired by reducing levels of an enzyme

In multiple sclerosis (MS), macrophages and microglia play a dual role that could be used to treat this neurodegenerative disease. These cells promote inflammation that demyelinates neurons but also sweep away the debris of damaged myelin and produce neurotrophic factors that would allow its restoration. According to a group of scientists from the University of Hasselt in Belgium, damage or repair depends on a double switch that combines the action of two enzymes, one that desaturates and another that elongates fatty acids. By reducing the levels of these enzymes, phagocytic cells would replenish the myelin instead of engulfing it. ....

Region Flamande , University Of Hasselt , Multiple Sclerosis , Hasselt University ,

Remyelinating drug shows potential to improve vision in patients with MS


Remyelinating drug shows potential to improve vision in patients with MS
A team led by a biomedical scientist at the University of California, Riverside, reports a drug an estrogen receptor ligand called indazole chloride (IndCl) has the potential to improve vision in patients with multiple sclerosis, or MS.
The study, performed on mice induced with a model of MS and the first to investigate IndCl s effect on the pathology and function of the complete afferent visual pathway, is published in
Brain Pathology. The afferent visual pathway includes the eyes, optic nerve, and all brain structures responsible for receiving, transmitting, and processing visual information. ....

United States , Riverside School , Seema Tiwari Woodruff , Johna Katzenellenbogen , Emily Henderson , University Of California , University Of Illinois At Urbana Champaign , Uc Riverside School Of Medicine , Multiple Sclerosis , Immune System , Mouse Model , Optic Neuritis , ஒன்றுபட்டது மாநிலங்களில் , ஆற்றங்கரை பள்ளி , சீமா திவாரி வூட்ரஃப் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் இல்லினாய்ஸ் இல் ஊர்பன சாம்பியன் , அக் ஆற்றங்கரை பள்ளி ஆஃப் மருந்து , பல ஸ்க்லரோசிஸ் , நோய் எதிர்ப்பு சக்தி அமைப்பு , சுட்டி மாதிரி ,