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CRISPR-SNP-chip enables amplification-free electronic detection of single point mutations


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VIDEO: Keck Graduate Institute (KGI) Assistant Professor and University of California, Berkeley Visiting Scientist Dr. Kiana Aran first introduced the CRISPR-Chip technology in 2019. Now just two years later, she has.
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Credit: Keck Graduate Institute (KGI) and Cardea Bio
CLAREMONT, CA - Keck Graduate Institute (KGI) Assistant Professor and University of California, Berkeley Visiting Scientist Dr. Kiana Aran first introduced the CRISPR-Chip technology in 2019. Now just two years later, she has expanded on its application to develop CRISPR-SNP-Chip, which enables detection of single point mutations without amplification in Sickle Cell Disease and Amyotrophic lateral sclerosis (ALS).
The field of CRISPR-based diagnostics is rapidly evolving due to CRISPR programmability and ease of use, Aran says. However, the majority of CRISPR-based diagnostics platforms are still relying on target amplifications or optical detections. The repr ....

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