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Proguanil and atovaquone use is associated with lower colorectal cancer risk: a nationwide cohort study | BMC Medicine

Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based evidence is still lacking. By accessing a couple of nationwide Swedish registers, we performed a cohort study to explore whether using proguanil and atovaquone might associate with a lower risk of CRC by adopting a new-user study design. Adults who have 1 or more first-degree relatives (parents or siblings) diagnosed with CRC were identified and linked with the Prescribed Drug Register to evaluate their administration history of proguanil and atovaquone. Survival analysis of the time to CRC diagnosis with Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 16,817 incident proguanil/atovaquone users were identified and matched with 168,170 comparisons, who did not use proguanil/atova ....

Lund Dnr , International Classification Of Diseases , National Patient Register , Regional Ethical Review Board , Swedish Multi Generation Register , Swedish Cancer Registry , International Classification , Swedish Prescribed Drug Register , Anatomical Therapeutic Chemical Classification , Death Register , Statistics Sweden , Total Population Register , Charlson Comorbidity Index , Swedish Prescribed Drug ,

Pseudophakia and Lens Opacities in 70-Year-Olds in Gothenburg, Sweden;

Identifying correlations between lens opacities, visual acuity and subjective visual function, and to validate self-reported cataract and cataract surgery ....

Vastra Gotalands Lan , Eteläuomen Läi , United States , Havstam Johansson , Pearson Chi Square , Heinrich Heine Universit , Los Angeles Latino , Pentacam Scheimpflug , National Eye Institute Visual Function Questionnaire , Sahlgrenska University Hospital , National Eye Institute Visual Functioning Questionnaire , Swedish National Cataract , Eye Diseases Prevalence Research , Cohort Study , Swedish Population , Early Treatment Diabetic Retinopathy Study Chart , Regional Ethical Review Board , Lens Opacities Classification System , Activity Limitations , Socio Emotional Functioning , Whitneyu Test , Self Reported Diagnosis , Previous Cataract Surgery , Year Old People , Previous Cataract , Lens Opacities ,

Hospital-treated infections in early- and mid-life and risk of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis: A nationwide nested case-control study in Sweden

In a nested case-control study, Jiangwei Sun and colleagues investigate the relationship between hospital-treated infections and risk of a diagnosis for Alzheimer’s disease, Parkinson’s disease, and ALS using nationwide registry data from 1970-2016 in Sweden. ....

Perminder Singh Sachdev , Swedish National Board Of Health , International Classification Of Disease , National Patient Register , Swedish Research Council , Program On Neurodegenerative Diseases , Swedish Ethical Review Authority , University Of New South Wales , Janssen Corporation , Chinese Scholarship Council , National Patient , New South Wales , Creative Commons Attribution License , Statistics Sweden , Swedish National Board , Swedish Ethical Review , Joint Program , Neurodegenerative Diseases , Death Register , International Classification , Swedish Multi Generation Register , Observational Studies , Regional Ethical Review Board , Alzheimers Disease , Parkinson Disease , Medical Risk Factors ,

Life among persons with prodromal Alzheimer's disease

Exploring the active everyday lives of persons with prodromal Alzheimer’s disease in terms of quality of participation in activities and perceived restrictions ....

Eteläuomen Läi , Regionala Etikpr , World Health Organization Active Ageing , World Health Organization , World Health , Active Ageing Policy , Multimodal Preventive Trials , Regional Ethical Review Board , World Medical Association , Incomplete Life , Desired Meaningful Activities , Feel Engaged , Bridge Base , Being Connected , Meaningful Context , Make Life , Making Decisions ,

Economic burden of generalized pustular psoriasis in Sweden

Study on a higher economic burden for generalized pustular psoriasis patients compared to both the general population and patients with psoriasis vulgaris ....

Eteläuomen Läi , United States , Sveriges Riksbank , Swedish National Patient Register , Total Population Register , Resource Use , Swedish Prescribed Drug Register , Anatomic Therapeutic Chemical Classification , Whitneyu Test , College Station , Regional Ethical Review Board , Study Populations Including , Matched Population Based Controls , Matched Controls , Outpatient Visits , Inpatient Stays During , Psoriasis Vulgaris Matched Controls , Use During , Matched Population Based , Psoriasis Vulgaris Controls , All Cause Healthcare Use , Costs Attributable , Resource Use Associated Specifically ,