Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based evidence is still lacking. By accessing a couple of nationwide Swedish registers, we performed a cohort study to explore whether using proguanil and atovaquone might associate with a lower risk of CRC by adopting a new-user study design. Adults who have 1 or more first-degree relatives (parents or siblings) diagnosed with CRC were identified and linked with the Prescribed Drug Register to evaluate their administration history of proguanil and atovaquone. Survival analysis of the time to CRC diagnosis with Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). A total of 16,817 incident proguanil/atovaquone users were identified and matched with 168,170 comparisons, who did not use proguanil/atova
Identifying correlations between lens opacities, visual acuity and subjective visual function, and to validate self-reported cataract and cataract surgery
In a nested case-control study, Jiangwei Sun and colleagues investigate the relationship between hospital-treated infections and risk of a diagnosis for Alzheimer’s disease, Parkinson’s disease, and ALS using nationwide registry data from 1970-2016 in Sweden.
Exploring the active everyday lives of persons with prodromal Alzheimer’s disease in terms of quality of participation in activities and perceived restrictions
Study on a higher economic burden for generalized pustular psoriasis patients compared to both the general population and patients with psoriasis vulgaris