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New findings linking brain immune system to psychosis

Credit: Stefan Zimmerman
New research at Karolinska Institutet in Sweden suggests a link between psychosis and a genetic change that affects the brain s immune system. The study published in
Molecular Psychiatry may impact the development of modern medicines for bipolar disorder or schizophrenia.
Psychosis affects approximately 2-3 per cent of the population and is characterized by a change in the perception of reality, often with elements of hallucinations and paranoid reactions.
Most of the people affected are patients with schizophrenia, but people with bipolar disorder may also experience psychotic symptoms.
The antipsychotics available today often have insufficient efficacy, and for patients, their life situation can be difficult. ....

United States , San Diego , Idaak Nilsson , Alfredo Oliveros , Martin Schalling , Michel Goiny , Anthi Faka , Tomas Hokfelt , Lilly Schwieler , Marie Svedberg , Mikael Landen , Markusk Larsson , Sophie Erhardt , Simone Codeluppi , Anton Schullman , Karolinska Institutet , Carl Sellgren , Magdalenae Kegel , Maximillian Tufvesson Alm , Camillai Svensson , Marquisp Vawter , Sorana Caldwell , Susanb Powell , Carlm Sellgren , Simon Cervenka , Marye Kamenski ,

Possible new PET tracer for early detection of Alzheimer's

Date Time
Possible new PET tracer for early detection of Alzheimer’s
New biomarkers for Alzheimer’s disease are a priority area for researchers seeking to learn more about the disease and find possible methods of early diagnosis. Researchers at Karolinska Institutet have now studied a new PET tracer that is an important diagnostic tool for the disease. The study on the tracer substance BU99008, which is published in Molecular Psychiatry, can play a key part in the early identification of signs of Alzheimer’s disease.
The binding of the PET-tracer BU99008 shows reactive astrogliosis in different parts of the brain of a deceased patient with Alzheimer’s disease. The colours show the extent of the binding, where green is low, yellow is medium, and red is high binding. Credit: Amit Kumar. ....

Uppsala Lan , United States , Karolinska Institutet , Inger Nennesmo , Martin Ingelsson , Agneta Nordberg , Amit Kumar , Niinaa Koistinen , Mona Lisa Malarte , Uppsala University , Department Of Neurobiology , Centre For Innovative Medicine , Indiana University School Of Medicine , Swedish Alzheimer Foundation , Tore Nilson Foundation , Foundation For Old Servants , Bertil Stohne Foundation , Swedish Dementia Association , Alzheimer Disease International , Swedish Research Council , Care Sciences , Swedish Brain Fund , Swedish Foundation For Strategic Research , Hans Osterman Medical Research Foundation , Molecular Psychiatry , Disease International ,

Possible new PET tracer for early detection of Alzheimer's

Possible new PET tracer for early detection of Alzheimer's
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Uppsala Lan , United States , Karolinska Institutet , Agneta Nordberg , Niinaa Koistinen , Inger Nennesmo , Amit Kumar , Mona Lisa Malarte , Martin Ingelsson , Uppsala University , Department Of Neurobiology , Centre For Innovative Medicine , Indiana University School Of Medicine , Swedish Alzheimer Foundation , Tore Nilson Foundation , Foundation For Old Servants , Bertil Stohne Foundation , Swedish Dementia Association , Alzheimer Disease International , Swedish Research Council , Josef Aner Foundation , Care Sciences , Swedish Brain Fund , Swedish Foundation For Strategic Research , Hans Osterman Medical Research Foundation , Molecular Psychiatry ,