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Key Protein Identified for Brain Stem Cell Longevity

INSR, a protein essential for insulin activity, plays a critical role in stem cell longevity. Additionally, inactivating INSR in glioblastoma brain cancer stem cells inhibits the growth of primitive tumor forming cells. ....

Shravanthi Chidambaram , Teresa Wood , Steven Levison , Cancer Institute Of New Jersey , Department Of Pharmacology , Rutgers New Jersey Medical School , Stem Cell Reports , Regenerative Neurobiology , Rutgers New Jersey Medical , Distinguished Professor , Rena Warshow Endowed Chair , Multiple Sclerosis , Cancer Institute , Press Office , Neuroscience Newsletter ,

Rutgers study identifies key protein for brain stem cell longevity

A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders. ....

Teresa Wood , Steven Levison , Emily Henderson , Cancer Institute Of New Jersey , Department Of Pharmacology , Rutgers New Jersey Medical School , Stem Cell Reports , Regenerative Neurobiology , Rutgers New Jersey Medical , Distinguished Professor , Rena Warshow Endowed Chair , Multiple Sclerosis , Cancer Institute , Medical School , Multiple Sclerosis , Nervous System , Neural Stem Cells , Stem Cells ,

Revival of the cell and gene therapy field opens new avenues for repairing the Parkinsonian brain

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. ....

New York , United States , United Kingdom , Patrik Brundin , Malin Parmar , Soania Mathur , Eli Lilly , Bastiaanr Bloem , Emily Henderson , Franz Hefti , Howard Federoff , Rogera Barker , Department Of Clinical Neuroscience , Parkinson Disease Center , Neuroscience Center , Department Of Neurodegenerative Science , University Of Cambridge , Cambridge Stem Cell Institute , Lund University , Department Of Experimental Medical Science , Van Andel Institute , Wallenberg Neuroscience Center , Parkinsonian Brain , Co Guest Editor , Disease Center , Neurodegenerative Science ,