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Secure Logistics : Corporate Announcement # 2

The Pakistan Credit Rating Agency Limited

Rating Report

Secure Logistics Group Limited
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"Venom-Derived Peptides Inhibiting Voltage-Gated Sodium and Calcium Cha" by Arsalan Yousuf, Mahsa Sadeghi et al.

Pain management is a serious worldwide problem that affects the physical and mental health of all affected humans. As an alternative to opioids, pharmaceutical companies are seeking other sources of potential analgesics that have fewer adverse side effects. Animal venoms are a natural cocktail of a complex mixture of salts, peptides, and proteins. Most animals that produce venoms release them for the purpose of prey capture and/or defense against other vertebrates. Over the last 30 years, many venom-derived peptides have been shown to be active against numerous voltage-gated ion channels in the mammalian somatosensory nervous system. Voltage-gated ion channels and in particular sodium, potassium, and calcium channels are fundamental to the transmission of all somatosensory information from the periphery to the central nervous system. This information can be chemical, mechanical, or thermal sensation that can result from touch to a more painful sensation of tissue injury. These voltage- ....

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