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Penn State researchers develop new method for creating cyclopropanes

Chemical structures called cyclopropanes can increase the potency and fine-tune the properties of many drugs, but traditional methods to create this structure only work with certain molecules and require highly reactive-;potentially explosive-;ingredients. Now, a team of researchers from Penn State has identified and demonstrated a safe, efficient and practical way to create cyclopropanes on a wide variety of molecules using a previously undescribed chemical process. ....

Majji Shankar , Ramesh Giri , Amrit Pokhrel , Danielle Ellis , Dhruba Poudel , Us National Institute , Eberly College Of Science , Pennsylvania State University , Drug Administration , Penn State , Eberly College , Pennsylvania State , Raj Kumar Tak , General Medical Sciences , Covid 19 , Drug Discovery , Hepatitis C , Hiv Aids ,

New, simple and accessible method creates potency-increasing structure in drugs

New, simple and accessible method creates potency-increasing structure in drugs
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Ramesh Giri , Amrit Pokhrel , Majji Shankar , Dhruba Poudel , Dhrubap Poudel , Drug Administration , Giri Lab Penn , Eberly College Of Science At Penn , Penn State , Eberly College , Raj Kumar Tak ,