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Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds


Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds
As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer s dementia. When they form around blood vessels in the brain, a condition known as cerebral amyloid angiopathy, the plaques also raise the risk of strokes.
Several antibodies that target amyloid plaques have been studied as experimental treatments for Alzheimer s disease. Such antibodies also may have the potential to treat cerebral amyloid angiopathy, although they haven t yet been evaluated in clinical trials. But all of the anti-amyloid antibodies that have successfully reduced amyloid plaques in Alzheimer s clinical trials also can cause a worrisome side effect: an increased risk of brain swelling and bleeds. ....

David Holtzman , Ralphg Dacey , Gretchenp Jones , Gregoryj Zipfel , Monica Xiong , Emily Henderson , Department Of Neurosurgery , Department Of Neurology , Washington University School Of Medicine , Washington University School , Science Translational Medicine , Distinguished Professor , Neurological Surgery , Blood Vessels , Alzheimer 39s Disease , டேவிட் ஹோல்ட்ஸ்மேன் , மோனிகா க்ஷ்ிொன் , எமிலி ஹென்டர்சன் , துறை ஆஃப் நரம்பியல் அறுவை சிகிச்சை , துறை ஆஃப் நரம்பியல் , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , வாஷிங்டன் பல்கலைக்கழகம் பள்ளி , அறிவியல் மொழிபெயர்ப்பு மருந்து , புகழ்பெற்ற ப்ரொஃபெஸர் , நரம்பியல் அறுவை சிகிச்சை , இரத்தம் நாளங்கள் ,

Protein linked to Alzheimer's, strokes cleared from brain blood vessels