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Simulations reveal how dominant SARS-CoV-2 strain binds to host, succumbs to antibodies
LOS ALAMOS, N.M., April 16, 2021 Large-scale supercomputer simulations at the atomic level show that the dominant G form variant of the COVID-19-causing virus is more infectious partly because of its greater ability to readily bind to its target host receptor in the body, compared to other variants. These research results from a Los Alamos National Laboratory–led team illuminate the mechanism of both infection by the G form and antibody resistance against it, which could help in future vaccine development.
“We found that the interactions among the basic building blocks of the Spike protein become more symmetrical in the G form, and that gives it more opportunities to bind to the receptors in the host in us,” said Gnana Gnanakaran, corresponding author of the paper published today in Science Advances. “But at the same time, that means antibodies can more easily ne ....

Gnana Gnanakaran , Los Alamos , Davidc Montefiori , Rachaela Mansbach , Kien Nguyen , Paul Weber , Bette Korber , Nonlinear Studies Postdoctoral Program At Los Alamos , Los Alamos National Laboratory , Los Alamos Laboratory Directed Research , Duke Human Vaccine Institute , Physics At Concordia University Srirupa Chakraborty , Concordia University , Srirupa Chakraborty , Duke Human Vaccine , Institutional Computing , Nonlinear Studies Postdoctoral Program , லாஸ் அலமோஸ் , கீேன் ஂக்யந் , பால் வெபர் , லாஸ் அலமோஸ் தேசிய ஆய்வகம் , லாஸ் அலமோஸ் ஆய்வகம் இயக்கியது ஆராய்ச்சி , டியூக் மனிதன் தடுப்பூசி நிறுவனம் , காணகார்டிங் பல்கலைக்கழகம் , டியூக் மனிதன் தடுப்பூசி , நிறுவன கணினி ,