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At the age of 42, Jeremy Kareken was exhausted, overweight and sad. “It took more of an effort to get out of bed and do the things I enjoyed,” says the playwright and actor, who lives between London and New York. “I was too tired to exercise, and when I did, the gains were much smaller; the gym was harder work. I had no sex drive. My two children, then aged six and three, were growing up, so I knew that wasn’t what was tiring me out. I was worried I was on a slow slide to the grave, with diminis ....

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