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Epigenetic Regulator Plays a Role in Drug Resistance in Some Lung Cancer Patients

A research team has discovered that epigenetic-modifying proteins contribute to drug resistance in some cases of non-small cell lung cancer. ....

Andrea Kasinski , Purdue University , National Institutes Of Health , College Of Science , Cancer Research , Department Of Biological Sciences In Purdue , Purdue Center , Purdue Institute For Drug Discovery , Purdue Research Foundation , Patty Miller Associate Professor , Biological Sciences , Purdue Institute , National Institutes ,

Epigenetic regulator explains why some lung cancer patients become resistant to common therapeutics

Doctors typically treat people with nonsmall cell lung cancer, a prevalent and typically incurable type of cancer that makes up 80%-85% of lung cancers, with tyrosine kinase inhibitors, specifically epidermal growth factor receptor inhibitors. About 15%-20% of these patients will become resistant to these standard treatments, resulting in their eventual death. Researchers understand part of the reason for this: The cells develop a mutation that leads to resistance. But about half of those resistant patients remain unexplained. Andrea Kasinski, a cellular biologist, and her lab have discovered that some of the explanation is epigenetic. When cells lose the histone methyltransferase (KMT5C), genes that KMT5C were repressing instead become expressed, leading to resistance to epidermal growth factor receptor inhibitors. This understanding lays the groundwork for future therapeutics and gives researchers and doctors a deeper insight into the biology and progression of cancers, especially th ....

Brittany Steff , Andrea Kasinski , Cancer Research , Purdue University , Purdue Research Foundation , Purdue Institute For Drug Discovery , Purdue Center , National Institutes Of Health , Patty Miller Associate Professor , Biological Sciences , Purdue Institute , National Institutes ,

Purdue University research instrumental in early development of FDA-approved advanced prostate cancer diagnostic and treatment

Prostate cancer is the second-most common cancer among American men after nonmelanoma skin cancer. According to the Centers for Disease Control and Prevention, it s also among the leading causes of cancer deaths in men. ....

United States , Ralphc Corley , Timothyl Ratliff , Robert Wallace Miller , Brooke Beier , Steve Martin , Purdue University , Centers For Disease , Us Services , Purdue Research Foundation Office Of Technology Commercialization , Institute For Drug Discovery , Drug Administration , Ipwatchdog Institute , Association Of Public , Office Of Technology Commercialization , Cancer Research , Purdue Research Foundation , Purdue Center , Purdue Institute For Drug Discovery , National Cancer , Convergence Center , Disease Control , Philip Low , Presidential Scholar , Drug Discovery , Distinguished Professor ,

New plant-based compounds have been created to treat alcohol use disorder

The 2019 National Survey on Drug Use and Health reported that 14.5 million people ages 12 and older have alcohol use disorder, or AUD. This represents 5.3% of that population, according to the National Institute on Alcohol Abuse and Alcoholism. ....

Van Rijn , Yazan Meqbil , Arryn Blaine , Richard Van Rijn , Annie Ghosh , Steve Martin , Susruta Majumdar , Purdue University , Us Services , Researchers In Purdue University College Of Pharmacy , Purdue Research Foundation Office Of Technology Commercialization , Sciences Pharmacy In St , Association Of Public , Purdue Research Foundation , Purdue Institute For Drug Discovery , Purdue University College Of Pharmacy , Ipwatchdog Institute , Us Drug Enforcement Agency , Purdue College Of Pharmacy , Office Of Technology Commercialization , National Survey On Drug , National Institute On Alcohol Abuse , University Of Health , University Of Health Science Pharmacy In St , Washington University In St , Convergence Center ,

Purdue researchers take successful steps in potential cancer treatment

Purdue researchers develop a enzyme mutation inhibitor that has shown advanced anti-tumor immune responses in mice studies. ....

Charlottep Anderson , Johns Hopkins University , Purdue University , Department Of Medicinal Chemistry , Purdue Institute For Drug Discovery , Lafayette Journal , Zhong Yin Zhang , Medicinal Chemistry , Molecular Pharmacology , Purdue Institute , Drug Discovery ,