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Background: Major depressive disorder (MDD) is the most prevalent mental disorder globally, with a greater morbidity rate among females than males. MDD encompasses both psychological and physical symptoms, and is associated with a higher risk of cardiometabolic disease (CMD), encompassing obesity, insulin resistance, dyslipidaemia, and hypertension. This is attributed to shared pathophysiology, including endocrine dysregulation, inflammation, and stress. However, there is limited understanding of the roles of and complex interactions between biological, psychological and physical contributors to the association between MDD and CMD. Prolactin, thyroid hormones, insulin and pro-inflammatory cytokines are implicated in the pathophysiology of both MDD and CMD. Prolactin is associated with stress and weight gain but there is limited research in MDD; cytokines are relevant to the inflammatory theory of MDD but sex differences have not been extensively examined; thyroid hormone dysfunction is ....
No matter how vacuous and empty a man’s brain is, his life partner should always be dumber. The Onion asked men why they prefer low-IQ wives, and this is what they said. ....
The Associated Press asked Iowa caucusgoers who they supported and questions about important topics. Check out the results below.AP VoteCast is a survey conduct ....