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DNAJC9 protein plays a key role in safeguarding histones, shows study


DNAJC9 protein plays a key role in safeguarding histones, shows study
In the cell nucleus histones play a crucial role packaging DNA into chromatin. Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right portion of DNA to organize the chromatin, they are guarded by complexes of histone chaperones.
Histone chaperones are proteins that bind to histones to help protect them from non-specific binding events until they reach their goal. This process fails sometimes and histones get stuck during their supply to chromatin without any purpose. ....

Colin Hammond , Hongyu Bao , Ivo Hendriks , Michael Lund Nielsen , Dinshaw Patel , Emily Henderson , Zhongda Huang , University Of Copenhagen , Proteomics Program , Southern University Of Science , Protein Memory Program , Protein Research At University Of Copenhagen , Novo Nordisk Foundation Center , Memorial Sloan Kettering Cancer Center , Molecular Cell , Protein Research , Assistant Professor , Southern University , Cell Nucleus , Protein Folding , கொலின் சுத்தி , டின்ஷா படேல் , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் , தெற்கு பல்கலைக்கழகம் ஆஃப் அறிவியல் , ப்ரோடீந் ஆராய்ச்சி இல் பல்கலைக்கழகம் ஆஃப் கோபெந்ஹேகந் ,