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Interferon-induced ACE2 production shown to be safe and even effective against COVID-19


11 Jan 2021
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While ACE2 proteins are known to be the vehicle used by COVID-19 to enter the nose and lungs, the previously worrying increase in ACE2 found to occur as a result of interferon treatment has been shown to include only a new, short version of the protein that cannot bind the SARS-CoV-2 virus. This both bodes well for interferon treatments and might even provide some protection against the virus.
A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to. ....

Donna Davies , Jane Lucas , Vito Mennella , Tom Wilkinson , Gabrielle Wheway , University Of Southampton , University Hospital Southampton , Professor Jane Lucas , Professor Donna Davies , Nature Genetics , Professor Tom Wilkinson , Paediatric Respiratory Medicine , டோனா டேவிஸ் , ஜேன் லூகாஸ் , டோம் வில்கின்சன் , பல்கலைக்கழகம் ஆஃப் சவுத்தாம்ப்டன் , பல்கலைக்கழகம் மருத்துவமனை சவுத்தாம்ப்டன் , ப்ரொஃபெஸர் ஜேன் லூகாஸ் , ப்ரொஃபெஸர் டோனா டேவிஸ் , இயற்கை ஜெநெடிக்ஸ் , ப்ரொஃபெஸர் டோம் வில்கின்சன் , குழந்தை சுவாச மருந்து ,