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A major breakthrough in targeting the causes of many diseases - proteins

Scientists at the University of Dundee have reported a major breakthrough in targeting the causes of many diseases, using a `kiss of death' to destroy proteins which had previously been regarded as `undruggable'. ....

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Dundee's CeTPD joins global fight against childhood cancer Labmate Online

The University of Dundee’s Centre for Targeted Protein Degradation CeTPD is contributing in a global effort to explore new means of tackling solid tumours in children. Click to read more. ....

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New class of 'intramolecular bivalent glue' could transform cancer drug discovery

New class of 'intramolecular bivalent glue' could transform cancer drug discovery
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Molecular glue could pave the way for new generation of drugs

A breakthrough class of molecular glue identified at the University of Dundee could pave the way for a new generation of drugs to target cancers and neurodegenerative diseases. ....

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Masking technique strategy targets proteins

Research led by Professor Alessio Ciulli at the University of Dundee’s recently opened Centre for Targeted Protein Degradation (CeTPD) has unlocked a class of proteins known as suppressor of cytokine signalling (SOCS), using a newly designed molecule that is able to target and bind to a protein class previously considered undruggable by using a masking technique to enter the cell. Click to read more. ....

Kevin Haubrich , Beth Forrester , Alessio Ciulli , Nikolai Makukhin , Sarath Ramachandran , Dylan Lynch , Ciulli Lab , Centre For Targeted Protein Degradation Ce , University Of Dundee , Nature Communications , Innovative Medicine Initiative , European Research Council , Professor Alessio Ciulli , Targeted Protein Degradation , Professor Ciulli , Trojan Horse ,