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Droplets of Unsaturated Fats Burden Human ApoE4 Astrocytes

12 Mar 2021
The E4 allele of the apolipoprotein E, a strong risk factor for many neurodegenerative diseases, most prominently late-onset Alzheimer’s disease, upsets the balance of lipids within cells. Exactly how ApoE4 does this remains unclear. In the March 3 Science Translational Medicine, researchers led by Li-Huei Tsai at MIT found that in human astrocytes and microglia, ApoE4 increased the amount of unsaturated lipids, which then accumulated in lipid droplets. Adding the phospholipid precursor choline to the cells restored their normal lipid metabolism, hinting at potential therapeutic approaches for ApoE4 carriers.
How exactly does ApoE4 lead to lipid imbalance in astrocytes? ....

Norra Savolax , Grzegorz Sienski , Susan Lindquist , Priyanka Narayan , Hilkka Soininen , Julia Bonner , Li Huei Tsai , Alois Alzheimer , Helen Santoro , Danone Research , University Of Eastern Finland , Translational Medicine , Eastern Finland , Genotype Tissue Expression , Kyoto Encyclopedia , Available Further , சூசன் லிண்ட்கிஸ்ட் , பிரியாங்க நாராயண் , ஜூலியா பொன்னர் , அலோயிஸ் முதுமறதி , ஹெலன் சாண்டோரோ , பல்கலைக்கழகம் ஆஃப் கிழக்கு பின்லாந்து , மொழிபெயர்ப்பு மருந்து , கிழக்கு பின்லாந்து , கியோட்டோ கலைக்களஞ்சியம் , கிடைக்கிறது மேலும் ,

Study offers an explanation for why the APOE4 gene enhances Alzheimer's risk

Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk
March 4, 2021MIT
The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed by choline
One of the most significant genetic risk factors for developing Alzheimer’s disease is a gene called APOE4, which is carried by almost half of all Alzheimer’s patients. A new study from MIT shows that this gene has widespread effects on brain cells’ ability to metabolize lipids and respond to stress.
In studies of human brain cells and yeast cells, the researchers found that the APOE4 gene significantly disrupts brain cells’ ability to carry out their normal functions. They also showed that treating these cells with extra choline, a widely available supplement that is considered safe for human use, could reverse many of these effects. ....

Grzegorz Sienski , Julia Maeve Bonner , Susan Lindquist , Stephen Ross , Priyanka Narayan , Li Huei Tsai , Helen Hay Whitney Foundation , Whitehead Institute For Biomedical Research , Damon Runyon Foundation , National Institutes Of Health , Picower Institute For , Reneee Belfer Foundation , Neurodegeneration Consortium , Ludwig Family Foundation , Howard Hughes Medical Institute , Biomedical Research , Science Translational , Julia Maeve , National Institutes , ஜூலியா மயெவ் பொன்னர் , சூசன் லிண்ட்கிஸ்ட் , ஸ்டீபன் ரோஸ் , பிரியாங்க நாராயண் , ஹெலன் வைக்கோல் விட்னி அடித்தளம் , வைட்ஹெட் நிறுவனம் க்கு உயிர் மருத்துவ ஆராய்ச்சி , டாமன் றுஞயோன் அடித்தளம் ,

Dietary Supplement Reverses Effects of Alzheimer's Disease APOE4 Risk Gene on Lipid Metabolism

A study by MIT researchers has provided new insights into the mechanisms by which a gene variant that is know to represent a risk factor for Alzheimer’s disease may impact on cellular lipid metabolism and stress response. Their studies in human brain cells and in yeast cells indicated how the APOE4 gene disrupts lipid homeostasis, and also showed that treating the cells with choline, a widely available dietary supplement, could reverse many of the effects of this disruption.
Headed by Li-Huei Tsai, PhD, director of MIT’s Picower Institute for Learning and Memory, the researchers hope that their findings may lead to clinical studies of choline specifically in people who carry the APOE4 gene, to see if the supplement could help to reduce the incidence of Alzheimer’s disease. Previous trials looking at choline’s effects on cognition have shown mixed results, but those trials were not targeted specifically to people with the APOE4 gene. The team is also now studying a mous ....

Grzegorz Sienski , Julia Maeve Bonner , Susan Lindquist , Priyanka Narayan , Li Huei Tsai , Whitehead Institute For Biomedical Research , Picower Institute For , Biomedical Research , Science Translational Medicine , ஜூலியா மயெவ் பொன்னர் , சூசன் லிண்ட்கிஸ்ட் , பிரியாங்க நாராயண் , வைட்ஹெட் நிறுவனம் க்கு உயிர் மருத்துவ ஆராய்ச்சி , உயிர் மருத்துவ ஆராய்ச்சி , அறிவியல் மொழிபெயர்ப்பு மருந்து ,