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Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD Anderson Cancer Center. ....

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Targeted oral therapy reduces disease burden and improves symptoms for patients with rare blood disorder in trial

Targeted oral therapy reduces disease burden and improves symptoms for patients with rare blood disorder in trial
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ASH: Oral Treatment Lowers Disease Impact in Rare Blood Disorder

ASH: Oral Treatment Lowers Disease Impact in Rare Blood Disorder
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Cogent Biosciences Announces Positive Initial Data from Phase 2 SUMMIT Trial Evaluating ...

Rapid and ongoing improvement in patient symptoms, with 57% median best improvement on MC-QoL and 78% of patients reporting ≥1 point improvement on PGIS by week 20 ....

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SUMMIT: Bezuclastinib Demonstrates Reduction in NonAdvSM Symptoms

Bezuclastinib, a targeted oral therapy, shows promise in reducing disease burden and improving symptoms by 50% or more in nonadvanced systemic mastocytosis patients, as revealed in the phase 2 SUMMIT trial data presented at ASH 2023. ....

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