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Can Huntington's disease clinical trial design tweaks lead to success?

After a series of disappointing clinical trial data in Huntington’s disease, study design changes take aim at moving the field forward. ....

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Huntington's disease setback for Roche shifts the research spotlight to Prilenia

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11 May, 2021
Author
Etain Lavelle
Huntington s disease research suffered a double whammy after Swiss pharmaceutical giant Roche Holding AG halted late-stage trials of an experimental medicine and Wave Life Sciences Ltd. abandoned two drug studies for futility.
Roche stopped dosing patients with tominersen after an independent data monitoring committee questioned whether the drug s benefits outweighed its risks.
Obviously, it s a very sad situation when we have to stop a pivotal program in a disease like Huntington s where there s such a high unmet need and such a terrible impact on these patients and their families, Bill Anderson, head of Roche s pharmaceuticals business, said on a call with reporters following Roche s first-quarter results. It s a major setback for the field. But we will do everything we can to learn from the work that s been done. And if there s a way forwa ....

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