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New molecule passes toxicology testing to treat multiple sclerosis

Brazilian researchers who study a native venomous fish have confirmed a route to drug development for the treatment of chronic inflammatory diseases such as multiple sclerosis and asthma. ....

Lopes Ferreira , Emily Henderson , Dissemination Centers Ridcs , Brazilian Multiple Sclerosis Association , Paulo Research Foundation , Butantan Institute Special Laboratory For Applied Toxinology , Research On Toxins , Zebrafish Network , South Asia , Butantan Institute , Special Laboratory , Applied Toxinology , Immune Response , Cell Signaling , Dissemination Centers , Toxicology Reports , Carla Lima , Zebrafish Platform , Multiple Sclerosis , Animal Model , Anti Inflammatory , In Vivo , லோப்ஸ் ஃபெரீரா , எமிலி ஹென்டர்சன் , பிரேசிலியன் பல ஸ்க்லரோசிஸ் சங்கம் , பாலொ ஆராய்ச்சி அடித்தளம் ,

Researchers confirm new drug development route for treating multiple sclerosis, asthma

Researchers confirm new drug development route for treating multiple sclerosis, asthma
Brazilian researchers who study a native venomous fish have confirmed a route to drug development for the treatment of chronic inflammatory diseases such as multiple sclerosis and asthma.
The venomous toadfish Thalassophryne nattereri contains a peptide (TnP) with anti-inflammatory and anti-allergic potential. Confirmation of this potential has now come via the zebrafish Danio rerio, a popular aquarium species native to South Asia that shares 70% of its genome with humans and is widely used as a model for in vivo trials in drug development.
The researchers tested TnP in D. rerio to measure its toxicity. In a little over a year, their research showed that the peptide is safe. It did not cause cardiac dysfunction or neurological problems in the toxicity tests they performed. ....

Lopes Ferreira , Emily Henderson , Dissemination Centers Ridcs , Brazilian Multiple Sclerosis Association , Paulo Research Foundation , Butantan Institute Special Laboratory For Applied Toxinology , Research On Toxins , Zebrafish Network , South Asia , Butantan Institute , Special Laboratory , Applied Toxinology , Immune Response , Cell Signaling , Dissemination Centers , Toxicology Reports , Carla Lima , Zebrafish Platform , Multiple Sclerosis , Animal Model , Anti Inflammatory , In Vivo , லோப்ஸ் ஃபெரீரா , எமிலி ஹென்டர்சன் , பிரேசிலியன் பல ஸ்க்லரோசிஸ் சங்கம் , பாலொ ஆராய்ச்சி அடித்தளம் ,

LAVA Therapeutics B.V. to Present Preclinical Findings Supporting Anti-Tumor Activity of Lead Clinical Candidate LAVA-051 at the American Association for Cancer Research (AACR) Virtual 2021 Annual Meeting

LAVA Therapeutics B.V., a biotechnology company focused on applying its expertise in bispecific gamma-delta T cell engagers (bsTCE) to transform cancer therapy, today announced that a poster featuring ....

United States , Kostenloser Wertpapierhandel , Keely Zipp , American Association For Cancer Research , American Association , Cancer Research , Annual Meeting , E Poster Session , Therapeutic Antibodies , Including Engineered Antibodies , ஒன்றுபட்டது மாநிலங்களில் , கீளி ஜிப்ப் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி , ஆண்டு சந்தித்தல் , ஏ போஸ்டர் அமர்வு , சிகிச்சை ஆன்டிபாடிகள் , உட்பட பொறியியலாளர் ஆன்டிபாடிகள் , வழி நடத்து ,

Inhibition of complement disrupts neurodegeneration, improves cognitive function in TBI patients

Traumatic brain injury (TBI) is a major cause of disability and a risk factor for early-onset dementia. The injury is characterized by a physical insult followed acutely by complement driven neuroinflammation. ....

Stephen Tomlinson , Emily Henderson , Ralphh Johnson Va Medical Center , Department Of Microbiology , University Of South Carolina , Tomlinson Lab , Medical University , South Carolina , Interim Chairman , Traumatic Brain Injury , Brain Cell , Head Injury , Immune System , ஸ்டீபன் டாம்லின்சன் , எமிலி ஹென்டர்சன் , துறை ஆஃப் நுண்ணுயிரியல் , பல்கலைக்கழகம் ஆஃப் தெற்கு கரோலினா , டாம்லின்சன் ஆய்வகம் , மருத்துவ பல்கலைக்கழகம் , தெற்கு கரோலினா , இடைக்கால தலைவர் , அதிர்ச்சிகரமான மூளை காயம் , மூளை செல் , தலை காயம் , நோய் எதிர்ப்பு சக்தி அமைப்பு ,

BerGenBio Presents Preclinical COVID-19 Data at Annual Conference on Retroviruses and Opportunistic Infections (CROI 2021)

BerGenBio Presents Preclinical COVID-19 Data at Annual Conference on Retroviruses and Opportunistic Infections (CROI 2021)
BERGEN, Norway, March 6, 2021 /PRNewswire/ BerGenBio ASA (OSE: BGBIO), a clinical-stage biopharmaceutical company developing novel, selective AXL kinase inhibitors for severe unmet medical need, today delivered a Science Spotlight oral presentation on preclinical COVID-19 data at the annual Conference on Retroviruses and Opportunistic Infections (CROI), taking place from 6-10 March 2021.
The presentation was led by BerGenBio s collaborator, Professor Wendy Maury, Professor of Microbiology and Immunology at the University of Iowa (Iowa City, USA), who presented data showing that AXL enhances the ability of SARS-CoV-2 to infect cell lines from the human airway, increasing the amount of virus measured in those cells. Treating the human cell lines, Vero E6 and human ACE2-expressing A549 lung cancer cell lines, with the AXL kinase inhibitor, bemcentinib r ....

South Africa , United States , United Kingdom , Wendy Maury , Chris Welsh , Carina Jurs , Richard Godfrey , Mary Jane Elliott , Prnewswire Bergenbio , Lucy Featherstone , University Of Iowa City , International Media Relations , Consilium Strategic Communications , Oslo Stock Exchange , Science Spotlight , Opportunistic Infections , Professor Wendy Maury , Iowa City , Jane Elliott , Petter Stiff , Crux Advisers , Norwegian Securities Trading , Co Vid , ஒன்றுபட்டது மாநிலங்களில் , ஒன்றுபட்டது கிஂக்டம் , வெண்டி ம Ury ரி ,