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ERSOY: Vegan vs. Carnivore — which one is healthier? (Part 2)

ERSOY: Vegan vs. Carnivore — which one is healthier? (Part 2)
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ProMIS Neurosciences Announces Abstracts Accepted for Presentation at the American Academy of Neurology 2023 Annual Meeting

TORONTO, Ontario and CAMBRIDGE, Massachusetts, March 13, 2023 (GLOBE NEWSWIRE) ProMIS Neurosciences Inc. (TSX: PMN) (Nasdaq: PMN), a biotechnology company… ....

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Omani research identifies COVID-19 specific miRNAs as a potential therapeutic target

The COVID-19 Research Program of the Ministry of Higher Education, Research and Innovation has showcased many innovative research projects on the coronavirus pandemic. ....

Ministry Of Health , Zuhair Al Sulti , Ministry Of Higher Education , Research Program , Sultan Qaboos University , Pharmacy Department At Al Nahdha Hospital , Higher Education , Potential Therapeutic Target , Pharmacy Department ,

Frontiers | Molecular Docking and Dynamics Studies to Explore Effective Inhibitory Peptides Against the Spike Receptor Binding Domain of SARS-CoV-2

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic due to the high transmission and mortality rate of this virus. The world health and economic sectors have been severely affected by this deadly virus, exacerbated by the lack of sufficient efficient vaccines. The design of effective drug candidates and their rapid development is necessary to combat this virus. In this study, we selected 23 antimicrobial peptides from the literature and predicted their structure using PEP-FOLD 3.5. In addition, we docked them to the SARS-CoV-2 spike protein receptor-binding domain (RBD) to study their capability to inhibit the RBD, which plays a significant role in virus binding, fusion and entry into the host cell. We used several docking programs including HDOCK, HPEPDOCK, ClusPro, and HawkDock to calculate the binding energy of the protein-peptide complexes. We identified four peptides with high binding free energy and docking scores. The docking results ....

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Macrodomains represent a unique target for pathogens with pandemic potential

In a new study published in the journal Pathogens, researchers have summarized the role of the macrodomain in viral replication and virulence and further reviewed the development of macrodomain inhibitors as antiviral agents. ....

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