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Gene Dyrk1a Linked to Heart Defects in Down Syndrome Identified

In Down syndrome patients, partially mitigating the overactivity of the Dyrk1a gene in mice reversed the defects laying the groundwork for potential future therapies. ....

Rifdat Aoidi , Victor Tybulewicz , Eva Lana Elola , Principal Laboratory Research Scientist , Postdoctoral Project Research Scientist , Science Translational Medicine , Missing Link , Down Syndrome Heart Defects , Group Leader , Immune Cell Biology Laboratory , Down Syndrome Laboratory , Down Syndrome , Heart Defects , Birth Defects ,

Gene behind heart defects in Down syndrome id

<p>Researchers at the Francis Crick Institute and UCL have identified a gene that causes heart defects in Down syndrome, a condition that results from an additional copy of chromosome 21.</p>

<p>Reducing the overactivity of this gene partially reversed these defects in mice, setting the scene for potential future therapies for heart conditions in people with Down syndrome.</p>
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City Of , United Kingdom , Rifdat Aoidi , Eva Lana Elola , Victor Tybulewicz , Method Of Research , Postdoctoral Project Research Scientist , Principal Laboratory Research Scientist , Times University Of The Year , University College London , London Global University , Imperial College London , Cancer Research United Kingdom , Research Council , Perha Pharmaceuticals , Francis Crick Institute , King College London , Science Translational Medicine , Group Leader , Immune Cell Biology Laboratory , Down Syndrome Laboratory , Medical Research Council , Sunday Times University ,