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Nashville woman becomes first in US to receive new 'Preeclampsia Test'

Tyesha Kinnard was the first woman in America to receive the FDA-approved preeclampsia test. The results of that test proved she was amid severe preeclampsia and at risk of losing her life and the life of her baby. ....

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Using health and care innovation to deliver a net zero NHS

Using health and care innovation to deliver a net zero NHS
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Frontiers | Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction



1Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States
2Molecular and Cellular Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, United States
3Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States
4Center for Translational Medicine, Temple University, Philadelphia, PA, United States
Background: Endothelial cells (ECs) play a critical role in the maintenance of vascular homeostasis and in heart function. It was shown that activated fibroblast-derived exosomes impair cardiomyocyte function in hypertrophic heart, but their effect on ECs is not yet clear. Thus, we hypothesized that activated cardiac fibroblast-derived exosomes (FB-Exo) mediate EC dysfunction, and therefore modulation of FB-exosomal contents may improve endothelial function. ....

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