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Telangana: Injections seized from firm in Asifabad district by DCA

Telangana: Injections seized from firm in Asifabad district by DCA
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Andhra Pradesh , Himachal Pradesh , Piperacillin Tazobactam , National Pharmaceutical Pricing Authority , Drug Control Administration , Prices Control , Maximum Retail Price ,

Cureus | Impact of Early Tracheostomy on Weaning From Ventilation and Sedation in COVID-19 Pregnant and Early Postpartum Patient: Two Case Reports

Pregnant women are at high risk of coronavirus disease 2019 (COVID-19) complications, including acute respiratory distress syndrome (ARDS) and the need for mechanical ventilation. There is no literature on the optimal strategy for the management of difficult-to-wean pregnant and early postpartum patients.

We report two cases of pregnant women with COVID-19 pneumonia and ARDS, who required mechanical ventilation and high doses of analgesia, and sedation with neuromuscular blocking agents to facilitate ventilation and oxygenation. Both patients had a tracheostomy procedure to facilitate weaning from mechanical ventilation and sedation. Shortly after tracheostomy, sedation and analgesia, along with ventilatory support were weaned off. Both patients were discharged home. These cases propose early tracheostomy as a strategy to facilitate weaning from mechanical ventilation and sedation in pregnant and early postpartum patients. ....

Piperacillin Tazobactam , World Health Organization , Middle Eastern , Richmond Agitation Sedation Scale ,

Cureus | A Rare Facultative Anaerobe Causing Emphysematous Osteomyelitis of the Pubic Bone

Emphysematous osteomyelitis is an uncommon and fatal disease that can only be confirmed with a contrast-enhanced CT scan showing characteristic features of air locules within the bone. It usually occurs in the setting of existing comorbidities and suppressed immune system resulting in widespread bacteremia which may be mono or poly-microbial. Presented here is a case of this disease caused by an unusual anaerobe affecting the pubic bone. This case emphasizes the importance of early imaging as it is crucial for the diagnosis and can facilitate early aggressive management. Moreover, it highlights the importance of early intravenous antibiotics and surgical intervention, which can be life-saving and result in a better outcome in the future. ....

Piperacillin Tazobactam , Coma Scale , Reactive Protein , Escherichia Coli ,

"Association Between Minimum Inhibitory Concentration, Beta-lactamase G" by A. Henderson, D. L. Paterson et al.

INTRODUCTION: This study aims to assess the association of piperacillin/tazobactam and meropenem minimum inhibitory concentration (MIC) and beta-lactam resistance genes with mortality in the MERINO trial. METHODS: Blood culture isolates from enrolled patients were tested by broth microdilution and whole genome sequencing at a central laboratory. Multivariate logistic regression was performed to account for confounders. Absolute risk increase for 30-day mortality between treatment groups was calculated for the primary analysis (PA) and the microbiologic assessable (MA) populations. RESULTS: In total, 320 isolates from 379 enrolled patients were available with susceptibility to piperacillin/tazobactam 94% and meropenem 100%. The piperacillin/tazobactam nonsusceptible breakpoint (MIC >16 mg/L) best predicted 30-day mortality after accounting for confounders (odds ratio 14.9, 95% confidence interval [CI] 2.8-87.2). The absolute risk increase for 30-day mortality for patients treated wit ....

Bloodstream Infection , Extended Spectrum Beta Lactamase , Piperacillin Tazobactam ,