Vonoprazan (Voquezna) is indicated for the healing and maintenance of healing of all grades of erosive esophagitis, as well as relief of associated heartburn in adults.
The risk for a dementia diagnosis before age 90 years was significantly higher among people with a history of PPI use, especially those who were diagnosed at a younger age.
Endoscopy with ambulatory reflux monitoring was the most cost-effective approach to managing patients with heartburn in whom empirical proton pump inhibitor therapy failed.