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Research Reveals Biological Factors Behind Heart Disease Risk

Research Reveals Biological Factors Behind Heart Disease Risk
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United States , Jesse Engreitz , Katherine Guo , Hilaryk Finucane , Erics Lander , X Rosa Ma , Ramcharans Angom , Alex Bloemendal , Ronghao Zhou , Tungh Nguyen , Glen Munson , Vivians Lee Kim , Nathan Cheng , Tony Zeng , Stephen Hinshaw , Oscar Sias Garcia , Gavinr Schnitzler , Shamsudheenk Vellarikkal , Philine Guckelberger , Krishna Aragam , Debabrata Mukhopadhyay , Helen Kang Stanford , Jessem Engreitz Stanford , Shi Fang , Martins Taylor , Rajat Gupta ,

New research uncovers biological drivers of h

<p>Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers led by investigators from <a href="https://brighamandwomens.org/" target=" blank">Brigham and Women’s Hospital</a>, a founding member of the <a href="https://www.massgeneralbrigham.org/" target=" blank">Mass General Brigham</a> healthcare system, in collaboration with the <a href="http://broadinstitute.org/" target=" blank">Broad Institute of MIT and Harvard</a> and Stanford Medicine, combined multiple sequencing and experimental techniques to map the rela ....

United States , Philine Guckelberger , Shamsudheenk Vellarikkal , Jessem Engreitz Stanford , Nathan Cheng , Martins Taylor , Ramcharans Angom , Oscar Sias Garcia , Alex Bloemendal , Katherine Guo , X Rosa Ma , Tony Zeng , Debabrata Mukhopadhyay , Erics Lander , Helen Kang Stanford , Jesse Engreitz , Glen Munson , Vivians Lee Kim , Gavinr Schnitzler , Stephen Hinshaw , Rajat Gupta , Krishna Aragam , Tungh Nguyen , Ronghao Zhou , Hilaryk Finucane , Shi Fang ,

Connecting enhancer variants, genes, and disease; synthetic spike binders; measuring tumors' cellular mix; and more

Posted April 9th, 2021 for Broad Institute
Welcome to the April 9, 2021 installment of Research Roundup , a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators.
Enhancing V2F maps
GWASs have yielded thousands of genetic variants linked to disease. To help figure out the function of many of these variants, Joseph Nasser (now at Caltech), Drew Bergman, Charles Fulco (now at Bristol Myers Squibb), Philine Guckelberger (now at the Free University of Berlin), Benjamin Doughty (now at Stanford University), Eric Lander (on leave), Jesse Engreitz (now at Stanford), and colleagues used their activity-by-contact (ABC) model to build maps that connect enhancers to their target genes in 131 cell types and tissues. Using those maps, the team linked more than 5,000 GWAS signals to nearly 2,250 genes across 72 traits and diseases. The researchers also predicted which enhancers contain risk variants for inflammat ....

Joseph Nasser , Wendy Garrett , Harvard Chan Microbiome , Curtis Huttenhower , Stefan Dentro , Guoping Feng , Ben Deverman , Kerstin Haase , Bradley Pentelute , Amit Deshwar , Eric Lander , Ignaty Leshchiner , Philine Guckelberger , Benjamin Doughty , Maxime Tarabichi , David Liu , Yulia Rubanova , Jesse Engreitz , Jeff Wintersinger , Charles Fulco , Jonas Demeulemeester , Broad Institute , Geoff Macintyre University Of Cambridge , Somatic Cell Genome Editing Consortium , Public Health Center , Stanley Center ,