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Novel Genetic Priority Score Unveiled to Enhance Target Prioritization in Drug Development

Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel ....

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"Genetic priority score" promises to revolutionize drug development

Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel "genetic priority score" (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score. ....

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Work with AI systems linked to loneliness and insomnia

Work with AI systems linked to loneliness and insomnia
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Insights into the role of DNA repair and Huntington's disease gene mutation open new avenues for drug discovery

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IMAGE: Timeline of some of the key events establishing anticipation as a genuine biological phenomenon and somatic expansion as contributing toward Huntington s disease pathology.
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Credit: : Darren G. Monckton in The Contribution of Somatic Expansion of the CAG Repeat to Symptomatic Development in Huntington s Disease: A Historical Perspective, Journal of Huntington s Disease 10:1 (February 2021)..
Amsterdam, February 11, 2021 - Recent genetic data from patients with Huntington s disease (HD) show that DNA repair is an important factor that determines how early or late the disease occurs in individuals who carry the expanded CAG repeat in the
HTT gene that causes HD. The processes of DNA repair further expand the CAG repeats in ....

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