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Atezolizumab Plus Cabozantinib Improves PFS Over Novel Hormonal Therapy in mCRPC

A significant progression-free survival improvement was achieved with cabozantinib plus atezolizumab vs second-line novel hormonal therapy in mCRPC. ....

Neeraj Agarwal , Global Health Status , University Of Utah , European Organization For Research , Genitourinary Oncology Gu Program , Huntsman Cancer Institute , Genitourinary Oncology , Investigational Therapeutics , European Organization , Cancer Quality , Cabozantinib Plus Atezolizumab , Metastatic Castration Resistant Prostate Cancer , 2024 Genitourinary Cancers Symposium , Phase 3 Contact 02 Trial ,

Atezolizumab Plus Cabozantinib Improves PFS in Hormone Therapy–Pretreated mCRPC

The combination of cabozantinib and atezolizumab led to a statistically significant improvement in progression-free survival compared with a second novel hormonal therapy in patients with metastatic castration-resistant prostate cancer and measurable soft tissue disease following 1 prior novel hormonal therapy, meeting one of the primary end points in the primary analysis of the phase 3 CONTACT-02 trial. ....

Howard Mayer , Vickil Goodman , Neeraj Agarwal , University Of Utah , Product Development Medical Affairs , Cancer Research At Huntsman Institute , Presidential Endowed Chair , Cancer Research , Huntsman Cancer Institute , Product Development , Medical Affairs , Immuno Oncology , Prostate Cancer , Metastatic Castration Resistant Prostate Cancer , Phase 3 Contact 02 Trial ,