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Have Children Truly Ever Been Therapeutic Orphans?

Imposing the FDA on-label/off-label framework on administratively defined "children" resulted in a regulatory demand for pediatric studies that had no basis in clinical medicine, with the exception of the small group of preterm newborns.

United statesBasel stadtUnited kingdomCity ofGianvincenzo zuccottiMassimo molteniHarry shirkeyEarlb ettienneJ clin pharmacologJ clin pharmacolKlaus roseEmilio clementiJapanese society for pediatric clinical pharmacologyCollege of pharmacyEuropean parliamentEuropean society for developmental

SGLT2 Inhibitors for Diabetes May Protect Against AKI, Increase UTI Risk

With increasing use of sodium glucose cotransporter 2 (SGLT2) inhibitors, investigators are taking a closer look at potential adverse events.

United statesSouth koreaBrian chiangMitsuboshi satoruBonggi kimJan menneKorean national health insurance serviceFlinders medical centreInternational journal of cardiologyPharmacology research perspectivesHannover medical school inKorea institute of drug safetyHarvard medical schoolHannover medical schoolAmerican journalKidney disease

SGLT2 Inhibitors for Diabetes May Protect Against AKI, Increase UTI Risk

With increasing use of sodium glucose cotransporter 2 (SGLT2) inhibitors, investigators are taking a closer look at potential adverse events.

United statesSouth koreaBrian chiangMitsuboshi satoruBonggi kimJan menneKorean national health insurance serviceFlinders medical centreInternational journal of cardiologyPharmacology research perspectivesHannover medical school inKorea institute of drug safetyHarvard medical schoolHannover medical schoolAmerican journalKidney disease

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