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The role of HER2 status and targeted therapy with trastuzumab in advanced endometrial cancer, emphasizing the need for effective management of cardiac toxicities and comorbidities.

Optimizing therapyEndometrial cancerRecent data highlightsPositive endometrial cancerTargeted approachHer2 positive endometrial cancerBiomarker driven treatmentFish testingCardiac toxicitiesChemotherapy re challengePrimary treatmentTreatment guidelinesPhase two trialPfs outcomesEchocardiogram monitoringMedical comorbidities