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New strategy to grow and measure how tumor organoids respond to therapy

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers. ....

United States , Los Angeles , Paul Boutros , Nasrin Tavanaie , Chuyen Nguyen , Sara Sartini , Alfredo Gonzalez , Thang Nguyen , Peyton Tebon , Brandon Tsai , Bowen Wang , Michael Teitell , Ardalan Davarifar , Eugenev Cota Robles , Alexander Markowitz , Danielle Ellis , Department Of Orthopaedic Surgery , National Institutes Of Health , David Geffen School Of Medicine , Department Of Defense , Jonsson Comprehensive Cancer Center , Office Of Scientific Research , Nature Communications , Los Angeles Health Sciences , University Of California , National Science Foundation Graduate Research Fellowship ,

Fine-tuning 3D lab-grown mini tumors to help

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers. ....

Michael Teitell , Alice Soragni , Ardalan Davarifar , Paul Boutros , Thang Nguyen , Alexander Markowitz , Brandon Tsai , Sara Sartini , Chuyen Nguyen , Nasrin Tavanaie , Eugenev Cota Robles , Peyton Tebon , Alfredo Gonzalez , Bowen Wang , Jonsson Comprehensive Cancer Center , Nature Communications , David Geffen School Of Medicine , National Institutes Of Health , Office Of Scientific Research , National Science Foundation Graduate Research Fellowship , Department Of Defense , Comprehensive Cancer Center , Orthopaedic Surgery , David Geffen School , Comprehensive Cancer , National Institutes ,

Breast cancer-on-a-chip for testing immunotherapy drugs


Credit: Khademhosseini Lab
(LOS ANGELES) - There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called checkpoint proteins. These checkpoint proteins bind to proteins on the surface of other cells and can result in either stimulation or suppression of T-cell activity. Normally, surface proteins on foreign or invading cells will produce a stimulation of T-cell activity against these cells, while T-cell suppression is a built-in mechanism to prevent the immune system from attacking the body s own normal cells. ....

Jixiang Zhu , Nureddin Ashammakhi , Praveen Bandaru , Junmin Lee , Samad Ahadian , Shiming Zhang , Xingwu Zhou , Yumeng Xue , Canran Wang , Qingzhi Wu , Stewart Han , Jun Kim , Wujin Sun , Jinhui Wu , Zhen Gu , Mehmetr Dokmeci , Peyton Tebon , Ali Khademhosseini , Terasaki Institute For Biomedical Innovation , Terasaki Institute , National Institutes Of Health , Biomedical Innovation , Haonan Ling , Han Jun Kim , National Institutes , ப்ரவீன் பண்டாரு ,