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Researchers uncover genetic factors for severe Lassa fever

Researchers uncover genetic factors for severe Lassa fever
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Fort Detrick , United States , Sierra Leone , Peter Okokhere , Pardis Sabeti , Siddharth Raju , Shervin Tabrizi , Ikponmwosa Odia , Dylan Kotliar , Broad Institute , African Center , Redeemer University , Harvard University , Research Facility , West Africa , Christian Happi , Infectious Diseases , Nature Microbiology , Irrua Specialist Teaching Hospital ,

Researchers uncover genetic factors for sever

<p>Researchers at the Broad Institute of MIT and Harvard&nbsp;and collaborators report the results of&nbsp;the first ever genome-wide association study (GWAS) of a biosafety level 4 (BSL-4) virus. The team found two key human genetic factors that could help explain why some people develop severe Lassa fever, and a set of <em>LARGE1 </em>variants linked to a reduced chance of getting Lassa fever. The work could lay the foundation for better treatments for Lassa fever and other similar diseases. The scientists are already working on a similar genetics study of Ebola susceptibility.</p>
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Sierra Leone , Peter Okokhere , Ikponmwosa Odia , Pardis Sabeti , Dylan Kotliar , Shervin Tabrizi , Los Angeles , Siddharth Raju , Redeemer University , Harvard University , Department Of Immunology , Method Of Research , Howard Hughes Medical Institute , German Research Foundation , Evolutionary Biology At Harvard University , Department Of Organismic , National Institute Of Health , African Center , Broad Institute , West Africa , Christian Happi , Infectious Diseases , Systems Biology , Evolutionary Biology , Infectious Disease , Chan School ,