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Blood Test Distinguishes Epileptic Seizures From PNES in Early Study

Target Audience and Goal Statement: Neurologists
The goal of this study was to assess a diagnostic test that stratifies epileptic seizures from psychogenic non-epileptic seizures (PNES) by developing a multimodal algorithm that integrates plasma concentrations of selected immune response-associated proteins and patient clinical risk factors for seizure.
Question Addressed:
Study Synopsis and Perspective:
Epilepsy affects over 70 million people worldwide. This common brain condition has multiple risk factors and a strong genetic predisposition.
Action Points
Four immune response-associated proteins TRAIL, ICAM-1, MCP-2, and TNF-R1 distinguished psychogenic non-epileptic seizures (PNES) from epileptic seizures with sensitivity of 82.6% and specificity of 91.6% when analyzed in a diagnostic algorithm, according to a recent small study. ....

United States , City Of , United Kingdom , San Francisco , Robert Jasmer , G Bryan Young , Peter Crino , John Gledhill , University Of California , University Of Maryland , University Of Western Ontario , Washington University In St , Elizabeth Brand , Liu Lin , Goal Statement , Western Ontario , Liu Lin Thio , Washington University , Clinical Professor , ஒன்றுபட்டது மாநிலங்களில் , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , சான் பிரான்சிஸ்கோ , க் பிரையன் இளம் , ஜான் க்லெட்‌ஹைல் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா ,

Epilepsy or Not?

A blood test differentiated epileptic from psychogenic non-epileptic seizures (PNES), a small study suggested.
Four immune response associated proteins TRAIL, ICAM-1, MCP-2, and TNF-R1 distinguished PNES from epileptic seizures with sensitivity of 82.6% (95% CI 62.9-93.0) and specificity of 91.6% (95% CI 74.2-97.7) when analyzed in a diagnostic algorithm, reported Peter Crino, MD, PhD, of University of Maryland in Baltimore, and co-authors.
Expanding the algorithm to include previously identified PNES risk factors boosted sensitivity to 91.3% (95% CI 73.2-97.6) and specificity to 95.8% (95% CI 79.8-99.3).
These four plasma proteins could provide a rapid, cost-effective, and accurate blood-based diagnostic test to confirm recent epileptic seizures or PNES, the researchers wrote in ....

City Of , United Kingdom , Judy George , G Bryan Young , Peter Crino , University Of Maryland , University Of Western Ontario , Washington University In St , Western Ontario , Liu Lin Thio , Washington University , Medpage Today , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , ஜூடி ஜார்ஜ் , க் பிரையன் இளம் , பல்கலைக்கழகம் ஆஃப் மேரிலாந்து , பல்கலைக்கழகம் ஆஃப் மேற்கு ஆஂடேரியொ , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , மேற்கு ஆஂடேரியொ , வாஷிங்டன் பல்கலைக்கழகம் ,