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The longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation

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Authors from the German Center for Diabetes Research (DZD) presented data showing that the longevity gene mammalian Indy (mINDY) is involved in blood pressure regulation in the
Journal of Clinical Investigation (JCI) insight. Reduced expression of mINDY, which is known to extend life span in lower organisms and to prevent from diet induced obesity, fatty liver and insulin resistance in mice, has now been shown to lower blood pressure and heart rate in rodents. The authors provided mechanistic insights for the underlying physiological mechanism based on in vivo data in a genetic knock out model as well as microarray and in vitro studies. Furthermore, the hypothesis is supported by confirming critical effects in vitro using a small molecule inhibitor of mINDY. The authors conclude that deletion of mIndy recapitulates beneficial cardiovascular and metabolic responses to caloric restriction, making it an attractive therapeutic target. ....

Baden Wuberg , Andreas Birkenfeld , Andreasl Birkenfeld , Department Of Internal Medicine , German Diabetes Center , German Research Center , Environmental Health , Diabetes Research , German Institute Of Human Nutrition Dif , Nephrology Of The University Hospital , German Center , Helmholtz Center Munich , University Hospital , Paul Langerhans Institute Dresden Of Helmholtz Zentrum , Institute Of Diabetes Research , Carl Gustav Carus University Hospital , German Centers For Health Research , Clinical Investigation , Metabolic Disorders , Im Not Dead , Internal Medicine , German Centers , Research Center , German Institute , Human Nutrition , Metabolic Diseases ,

Type 2 Diabetes: New Evidence Underlines the Role of Obesity in Late Complications

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IMAGE: The researchers examined data from study participants of the EPIC-Potsdam study who developed type 2 diabetes during the follow-up of the study. Thus, an increase in risk for microvascular complications.
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Credit: Source: DIfE
Successful weight loss is considered to be an integral part of the therapy for type 2 diabetes. Nevertheless, studies keep appearing that question the importance of losing weight. However, new data from a large-scale observational study carried out at DIfE in cooperation with the German Center for Diabetes Research (DZD) support the current recommendations of physicians. The findings, published in the journal
Diabetologia, suggest that obesity and weight gain can lead to vascular disorders, the leading cause of disease and death for people with type 2 diabetes. ....

Baden Wuberg , Elli Polemiti , Rehbruecke Dif , Matthias Schulze , German Diabetes Center , Head Of The Department Molecular Epidemiology , Environmental Health , University Medical Center Carl Gustav Carus , German Institute Of Human Nutrition Potsdam , Paul Langerhans Institute Dresden Of Helmholtz Zentrum , Leibniz Association , Institute Of Diabetes Research , Ministry Of Education , German Research Center , Diabetes Research , World Health Organization , German Institute Of Human Nutrition Dif , German Center , Department Of Molecular Epidemiology , German Centers For Health Research , Molecular Epidemiology , Professor Matthias Schulze , German Institute , Human Nutrition Potsdam Rehbruecke , European Prospective Investigation , Public Relations ,

The interconnection of global pandemics -- Obesity, impaired metabolic health and COVID-19

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IMAGE: Obesity and cardiometabolic diseases do not only trigger a more severe course of COVID-19, the SARS-CoV-2 infection could promote the development of these conditions.
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Credit: Norbert Stefan
In a
Nature Reviews Endocrinology article authors from the German Center for Diabetes Research (DZD) highlight the interconnection of obesity and impaired metabolic health with the severity of COVID-19. First, they provide information about the independent relationships of obesity, disproportionate fat distribution and impaired metabolic health with the severity of COVID-19. Then they discuss mechanisms for a complicated course of COVID-19 and how this disease may impact on the global obesity and cardiometabolic pandemics. Finally, they provide recommendations for prevention and treatment in clinical practice and in the public health sector to combat these global pandemics. ....

Baden Wuberg , Andreas Birkenfeld , Norbert Stefan , Matthias Schulze , Department Of Internal Medicine , German Diabetes Center , German Research Center , Diabetes Research , Environmental Health , German Institute Of Human Nutrition Dif , German Center , Paul Langerhans Institute Dresden Of Helmholtz Zentrum , University Hospital , Institute Of Diabetes Research , Carl Gustav Carus University Hospital , German Centers For Health Research , Nature Reviews Endocrinology , Internal Medicine , German Centers , Research Center , German Institute , Human Nutrition , Metabolic Diseases , Paul Langerhans Institute Dresden , ஆண்ட்ரியாஸ் பிர்கன்பெல்ட் , நோர்பர்ட் ஸ்டீபன் ,