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Emerging Bispecifics in the Treatment Paradigm for R/R LBCL

Expert discusses the emergence of recently approved bispecific antibodies in R/R LBCL, emphasizing the importance of toxicity management for adverse events such as cytokine release syndrome (CRS). ....

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Future Perspectives in Large B-Cell Lymphoma

Fred Locke, MD shares his perspective on the future treatment paradigm in large B-cell lymphoma, emphasizing CAR-T cells, allogeneic strategies, bispecifics, toxicity management, and treatment sequencing. ....

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Exploring LBCL: Transplant Eligibility and Second Line Treatment Selection of Novel Agents

Fred Locke, MD, provides an overview of transplant eligibility for patients with large B-cell lymphoma, highlighting second line strategies with CAR T-cell therapy and bispecific antibodies. ....

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CAR T: A Review of Clinical Data for Second Line Treatments of Large B-Cell Lymphoma

Dr. Locke reviews the latest data from ZUMA-7 and TRANSFORM studies, evaluating CAR T in the second line setting for R/R LBCL. ....

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Second-Line Axi-Cel Elicits Complete Metabolic Responses in Transplant-Ineligible LBCL

Second-line treatment with axicabtagene ciloleucel led to an investigator-assessed, 3-month complete metabolic response rate of 71.0% in patients with large B-cell lymphoma who were ineligible for autologous stem cell transplant. ....

Francois Lemonnier , International Prognostic Index , Lymphoid Malignancies Unit , Henri Mondor University Hospital , Ann Arbor , Second Line Treatment With Axicabtagene Ciloleucel , Patients With Largeb Cell Lymphoma , Alycante Trial ,