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Frontiers | An Update on Protective Effectiveness of Immune Responses After Recovery From COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits variable immunity responses among hosts based on symptom severity. Whether immunity in recovered individuals is effective for avoiding reinfection is poorly understood. Determination of immune memory status against SARS-CoV-2 helps identify reinfection risk and vaccine efficacy. Hence, after recovery from COVID-19, evaluation of protective effectiveness and durable immunity of prior disease could be significant. Recent reports described the dynamics of SARS-CoV-2 -specific humoral and cellular responses for more than six months in convalescent SARS-CoV-2 individuals. Given the current evidence, NK cell subpopulations, especially the memory-like NK cell subset, indicate a significant role in determining COVID-19 severity. Still, the information on the long-term NK cell immunity conferred by SARS-CoV-2 infection is scant. The evidence from vaccine clinical trials and observational studies indicates that hybrid natural/ ....

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Frontiers | Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

Frontiers | Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era
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Frontiers | Chronic Obstructive Pulmonary Disease Patients Have Increased Levels of Plasma Inflammatory Mediators Reported Upregulated in Severe COVID-19

2Informatic Unit, INMEDIT SAS and Faculty of Engineering, University of Cartagena, Cartagena, Colombia
3Clinica Respiratoria y de Alergias, Cartagena, Colombia
4Departamento de Investigaciones, Fundación Cardioinfantil, Bogotá, Colombia
5Research Department - CINEUMO, Fundación Neumológica Colombiana, Bogotá, Colombia
6Research Department and Specialization Program in Pulmonology, Universidad de la Sabana, Bogotá, Colombia
Background: Chronic obstructive pulmonary disease (COPD) is associated with increased risk of severe COVID-19, but the mechanisms are unclear. Besides, patients with severe COVID-19 have been reported to have increased levels of several immune mediators.
Methods: Ninety-two proteins were quantified in 315 plasma samples from 118 asthmatics, 99 COPD patients and 98 healthy controls (age 40-90 years), who were recruited in Colombia before the COVID-19 pandemic. Protein levels were compared between each disease group and healthy contro ....

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Feature | Responding to a Pandemic: The Building of ACC's COVID-19 Hub - American College of Cardiology

Feature | Responding to a Pandemic: The Building of ACC s COVID-19 Hub
Feb 17, 2021
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It was one year ago in March that the ACC released its first clinical bulletin addressing the cardiac implications of the novel SARS-CoV-2 (COVID-19) virus initially originating in Wuhan, China, and quickly making its way around the world.
The bulletin provided background on what was soon to be an official global pandemic, assessed information on the potential cardiac implications based on analog viral respiratory pandemics and offered early clinical guidance.
Of note, the bulletin cautioned clinicians to be prepared for guidance to shift as more information became available, especially given the speed at which the virus was spreading and the uncertain clinical profile. ....

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