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Insights on the Pathophysiology of Schizophrenia

Two experts in the management of schizophrenia provide further insights on the disease pathophysiology, highlight the inflammatory impact on dendritic spines, and explore treatment considerations for this condition. ....

Shaping-schizophrenia-care , Cognitive-impairment , Schizophrenia , Pathophysiology , Inflammatory-response , Nmda ,

Implications for pathophysiology and therapeutics in chronic inflammatory disorder

This article explores the role of citrullination, a post-translational modification process, in the pathogenesis of chronic diseases such as rheumatoid arthritis, cancer, and neurodegenerative disorders ....

Ireland , United-states , San-diego , California , Maria-osipova , Sonoma-biotherapeutics , Sengenics-corporation , Cancer-research , Sengenics-corporation-llcapr , American-college-of-rheumatology , American-college-of-rheumatology-convergence , Autoimmune-autoantigen-panel

Targeting T-Cell–Based Therapies to Treat Alopecia Areata

New research explores T cells and their signaling pathways in alopecia areata (AA), highlighting promising drug targets for future treatment. ....

Image-credit , Alopecia-areata , Janus-kinase-inhibitors , Jak-inhibitors , T-cells , Baricitinib , Ritlecitinib , Hair-follicles , Hepatocellular-carcinoma , Antigens , Immune-privilege

Future EoE Treatments and Practices

Mirna Chehade, MD, MPH, discusses ongoing trials for emerging therapies in eosinophilic esophagitis (EoE), her views on the use of combination therapies, and the importance of shared decision-making for the chronic management of EoE throughout the different phases of a patient’s life. ....

Mirna-chehade , Eosinophilic-esophagitis , Ceoe , Pathophysiology , Age-dependent , Symptoms , Dysphagia , Gi-symptoms , Pediatric-diagnosis , Failure-to-thrive , Feeding-difficulties

Overcoming Treatment Challenges in EoE

Mirna Chehade, MD, MPH, discusses the challenges faced by patients with eosinophilic esophagitis (EoE), including the absence of predictive factors for personalized treatment, the social implications of dietary restrictions, and the need for invasive procedures, while emphasizing the importance of regularly scheduled follow-up visits to address medical, nutritional, and psychosocial factors for better outcomes. ....

Mirna-chehade , Eosinophilic-esophagitis , Ceoe , Pathophysiology , Age-dependent , Symptoms , Dysphagia , Gi-symptoms , Pediatric-diagnosis , Failure-to-thrive , Feeding-difficulties