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"Molecular characterization of the interaction between human IgG and th" by Emma Jayne Proctor, Hannah R. Frost et al.

Group A Streptococcal M-related proteins (Mrps) are dimeric α-helical-coiled-coil cell membrane-bound surface proteins. During infection, Mrp recruit the fragment crystallizable region of human immunoglobulin G via their A-repeat regions to the bacterial surface, conferring upon the bacteria enhanced phagocytosis resistance and augmented growth in human blood. However, Mrps show a high degree of sequence diversity, and it is currently not known whether this diversity affects the Mrp–IgG interaction. Herein, we report that diverse Mrps all bind human IgG subclasses with nanomolar affinity, with differences in affinity which ranged from 3.7 to 11.1 nM for mixed IgG. Using surface plasmon resonance, we confirmed Mrps display preferential IgG-subclass binding. All Mrps were found to have a significantly weaker affinity for IgG3 (p < 0.05) compared to all other IgG subclasses. Furthermore, plasma pulldown assays analyzed via Western blotting revealed that all Mrp were able to bind IgG ....

Groupa Streptococcal , Streptococcalm Related , Binding Affinity , Inding Stoichiometry , Groupa Streptococcus , Mmunoglobulin G , M Protein Family , M Related Protein , Streptococcus Pyogenes , Ubclass Preferences ,

Study Finds AA Associated With Connective Tissue, Ocular Diseases and Vitamin D Deficiency

Meta-analysis results identify high and low associations of various comorbidities like vitamin D deficiencies, ocular diseases, among others in patients with alopecia areata (AA), to promptly manage and improve treatment outcomes. ....

Image Credit , Preferred Reporting Items , Systematic Reviews , Alopecia Areata , Vitamind Deficiency , Systemic Lupus Erythematous , Hashimoto Thyroiditis , Thyroid Disease , Ocular Disease , Metabolic Syndrome , Colorectal Cancer , Irritable Bowl Syndrome , Connective Tissue , Autoimmune Diseases ,

IBD is Milder, With Later Onset, in Non-US Born Patients

Race and immigration status were both found to influence inflammatory bowel disease manifestations, which may aid in clinical management. ....

New York , United States , Ali Khalessi , School Of Medicine , New York City , Gastro Hep , Inflammatory Bowel Disease Ibd , Clinical Management , Crohn Amp 039s Disease , Crohn Disease , Egional Enteritis Crohn S , Gastric Flu , Stomach Flu , Medical Records , Diarrhea Diarrhoea , Neuroendocrine Tumor Tumour , Euroendocrine Tumor Net ,

Musculoskeletal Symptoms Often Misattributed to Tick Bites

A new study failed to find an association between prior exposure to tick bites and chronic musculoskeletal symptoms and radiographic measures of osteoarthritis. ....

United States , North Carolina , University Of North Carolina , Johnston County , Dianal Zychowski , University Of North Carolina At Chapel Hill , Division Of Infectious Diseases , Infectious Diseases , Chapel Hill , Johnston County Osteoarthritis , Black Johnston County , Ehrlichia Igg , Tropical Infection , Ropical Disease , Osteoarthritis Generalized Oa Djd Degenerative Joint Disease Arthritis Generalised , Osteoarthritis Oa , Immunoglobulin E , Mmunoglobulin G , Pain Management , Knee Pain , Immunoglobulin A , Lyme Disease , Oint Inflammation ,

Environmental Exposure to Toxic Metals May Increase Risk of MASLD, Study Finds

Greater selenium and lead exposure were associated with an increased risk of MASLD, with further analysis suggesting potential synergistic interactions between different metals and their joint effects on MASLD risk. ....

United States , Li Yuguang , Nutrition Examination Survey , Jilin University , National Health , National Center , Centers For Disease , Health Statistics , Disease Control , Weighted Quantile Sum , Accessed December , Metabolic Dysfunction Associated Steatotic Liver Disease , Nonalcoholic Fatty Liver Disease ,