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St. Jude tool targets cancer-causing fusions' weak spot

St. Jude tool targets cancer-causing fusions' weak spot
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

Jim Wang , Todd Alonzo , Richa Bajpai , Li Dong , Quang Tran , Jonathon Klein , Pandurang Kolekar , David Wheeler , Heather Mulder , Jenny Smith , Michael Walsh , Junj Yang , Soheil Meshinchi , Robert Autry , John Easton , Jinghui Zhang , Timothy Shaw , Yanling Liu , William Evans , Jing Ma , Shondra Pruett Miller , Benjamin Huang , Tamara Westover , Xiaotu Ma , Jeffery Klco , Patrick Brown ,

Research reveals high-risk subtype of relapsed pediatric AML

Research reveals high-risk subtype of relapsed pediatric AML
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

United States , Michael Rusch , Andrew Mcdonough , Yen Chun Liu , Benjamin Huang , Ryan Hiltenbrand , Madan Babu , Tamara Westover , John Easton , Xiaotu Ma , Jeffrey Rubnitz , Jeffery Klco , Evan Parganas , Michael Walsh , Jonathan Miller , Andrew Kleist , Jinghui Zhang , Amanda Leonti , Delaram Rahbarinia , Sherif Abdelhamed , Jamesr Downing , Jamie Maciaszek , Pandurang Kolekar , Scott Foy , Jenny Smith , Huiyun Wu ,

Research finds high-risk subtype of relapsed pediatric AML

Research finds high-risk subtype of relapsed pediatric AML
miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.

United States , Michael Rusch , Andrew Mcdonough , Yen Chun Liu , Benjamin Huang , Ryan Hiltenbrand , Madan Babu , Tamara Westover , John Easton , Xiaotu Ma , Jeffrey Rubnitz , Jeffery Klco , Evan Parganas , Michael Walsh , Jonathan Miller , Andrew Kleist , Jinghui Zhang , Amanda Leonti , Delaram Rahbarinia , Sherif Abdelhamed , Jamesr Downing , Jamie Maciaszek , Pandurang Kolekar , Scott Foy , Jenny Smith , Huiyun Wu ,

Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients

Chemotherapy drugs can induce mutations that lead to relapse in pediatric ALL patients
Chemotherapy has helped make acute lymphoblastic leukemia (ALL) one of the most survivable childhood cancers. Now, researchers working in the U.S., Germany and China have shown how chemotherapy drugs called thiopurines can lead to mutations that set patients up for relapse. The work appears today in the journal
Nature Cancer.
The research provides the first direct genomic and experimental evidence in pediatric cancer that drug-resistant mutations can be induced by chemotherapy and are not always present at diagnosis.
The findings offer a paradigm shift in understanding how drug resistance develops. The results also suggest possible treatment strategies for ALL patients who relapse, including screening to identify those who should avoid additional thiopurine treatment. ....

Yao Chen , Chao Tang , Fan Yang , Li Xia , Bing Zhou , Benshang Li , Pandurang Kolekar , Huiying Sun , Hongzhuan Chen , Cornelia Eckert , Emily Henderson , Houshun Fang , Tianyi Wang , Jeffery Klco , Xiaotu Ma , Omkar Pathak , Jiaoyang Cai , Jinghui Zhang , Renate Kirschner Schwabe , Samuel Brady , Xiaomeng Li , Malwine Barz , Caiwen Duan , Shuhong Shen , Yu Liu , Shanghai Jiao Tong University School Of Medicine ,