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New Protein Target TAp63 Discovered for Rheumatoid Arthritis

New Protein Target TAp63 Discovered for Rheumatoid Arthritis
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Akiro Suto , Hiroshi Nakajima , Osamu Ohara , Akira Suto , Kensuke Suga , Shigeru Tanaka , School Of Medicine , Chiba University , Department Of Applied Genomics , Department Of Allergy , School Of Medicine At Chiba University , Research Institute , Clinical Immunology At Chiba University , Associate Professor , Clinical Immunology , Graduate School , Advanced Academic Research , Applied Genomics ,

TAp63: A new protein drug target for rheumato

Methotrexate (MTX) is a first-line treatment in the fight against rheumatoid arthritis (RA) an autoimmune disease characterized by joint deterioration. However, the precise therapeutic mechanisms of MTX are poorly understood. Now, researchers from Chiba University reveal that a variant of tumor protein p63, TAp63, is suppressed by MTX, which in turn suppresses the expression of another protein, Foxp3, and aggravates RA. ....

Akiro Suto , Akira Suto , Hiroshi Nakajima , Kensuke Suga , Shigeru Tanaka , Osamu Ohara , Department Of Allergy , Method Of Research , School Of Medicine , Department Of Applied Genomics , Research Institute , Clinical Immunology At Chiba University , Chiba University , School Of Medicine At Chiba University , Associate Professor , Clinical Immunology , Graduate School , Advanced Academic Research , Applied Genomics ,